[通过母体静脉注射免疫球蛋白对新生儿血色病进行产前治疗（约4例）]

[Prenatal treatment of neonatal hemochromatosis with maternal administration of intravenous immunoglobulins (about four cases)].

作者信息

Paupe A, Duclos B, Leroy B, Molho M

机构信息

Département de gynécologie-obstétrique et médecine néonatale, hôpital Poissy-Saint-Germain, université Versailles-Saint-Quentin, 10 rue du Champ-Gaillard, Poissy cedex, France.

出版信息

Gynecol Obstet Fertil. 2011 Jul-Aug;39(7-8):418-24. doi: 10.1016/j.gyobfe.2011.03.015. Epub 2011 Jul 13.

DOI:10.1016/j.gyobfe.2011.03.015

PMID:21742537

Abstract

OBJECTIVES

Neonatal hemochromatosis is a very bad prognosis disease; liver transplantation was the only way to avoid an unfavourable evolution. Nowadays, hypothesis of an alloimmune mechanism for this disease has purposed to administrate high doses of immunoglobulins.

PATIENTS AND METHODS

In this study, we report four cases of women whose previous child had neonatal hemochromatosis and who received such a treatment during the next pregnancy from 18 weeks to the term.

RESULTS

This treatment allowed to lead their pregnancy to success. At birth, all four neonates were alive. Two of them presented transitory biologic symptoms of liver deficiency. All had a favourable evolution later.

DISCUSSION AND CONCLUSION

Maternal treatment with high doses of immunoglobulins during pregnancy seems to improve dramatically the prognosis of neonatal hemochromatosis as it has been already reported. It could also apply to other diseases, which proceed from the same mechanism.

摘要