Paupe A, Duclos B, Leroy B, Molho M
Département de gynécologie-obstétrique et médecine néonatale, hôpital Poissy-Saint-Germain, université Versailles-Saint-Quentin, 10 rue du Champ-Gaillard, Poissy cedex, France.
Gynecol Obstet Fertil. 2011 Jul-Aug;39(7-8):418-24. doi: 10.1016/j.gyobfe.2011.03.015. Epub 2011 Jul 13.
Neonatal hemochromatosis is a very bad prognosis disease; liver transplantation was the only way to avoid an unfavourable evolution. Nowadays, hypothesis of an alloimmune mechanism for this disease has purposed to administrate high doses of immunoglobulins.
In this study, we report four cases of women whose previous child had neonatal hemochromatosis and who received such a treatment during the next pregnancy from 18 weeks to the term.
This treatment allowed to lead their pregnancy to success. At birth, all four neonates were alive. Two of them presented transitory biologic symptoms of liver deficiency. All had a favourable evolution later.
Maternal treatment with high doses of immunoglobulins during pregnancy seems to improve dramatically the prognosis of neonatal hemochromatosis as it has been already reported. It could also apply to other diseases, which proceed from the same mechanism.
新生儿血色病是一种预后很差的疾病；肝移植是避免不良进展的唯一方法。如今，关于该疾病的同种免疫机制假说促使人们给予高剂量免疫球蛋白。
在本研究中，我们报告了4例女性病例，她们的前一个孩子患有新生儿血色病，且在下一次妊娠18周直至足月期间接受了此类治疗。
这种治疗使她们的妊娠成功。出生时，所有4例新生儿均存活。其中2例出现了短暂的肝功能不足生物学症状。后来所有患儿的病情均得到了良好发展。
正如之前所报道的，孕期给予母体高剂量免疫球蛋白治疗似乎能显著改善新生儿血色病的预后。它也可能适用于由相同机制引发的其他疾病。
