Cui S X
General Hospital, PLA.
Zhonghua Zhong Liu Za Zhi. 1990 May;12(3):227-30.
One hundred and forty cases of pituitary adenoma, treated by surgery plus radiotherapy or radiotherapy alone from 1978 to 1985, were analysed as to the incidence of hypothalamo-pituitary and peripheral target-gland hypofunction after radiotherapy. The incidence of hypothyroidism, hypogonadism and hypoadrenalism was 51.7%, 61.4% and 17.8%, respectively. Thyroid and gonad were vulnerable following hypothalamo-pituitary hypofunction, and the incidence was 19.2% and 23.5% individually, and 27.1% simultaneously. The incidence of hypoadrenalism was 7.1%. The total incidence of target-gland hypofunction was 10.7%. Hypofunction of the posterior lobe of the pituitary often occurred after operation. For patients treated with radiotherapy alone, the incidence of hypothalamo-pituitary and target-gland hypofunction was high because of higher irradiation dose. Hormonotherapy was successful in the treatment of hypopituitarism and target-gland hypofunction. For radiotherapy of pituitary adenoma, DT 40-45 Gy and treatment field 4 x 4 cm are recommended.
对1978年至1985年间采用手术加放疗或单纯放疗治疗的140例垂体腺瘤患者，分析放疗后下丘脑 - 垂体及外周靶腺功能减退的发生率。甲状腺功能减退、性腺功能减退和肾上腺皮质功能减退的发生率分别为51.7%、61.4%和17.8%。下丘脑 - 垂体功能减退后甲状腺和性腺易受累，单独发生率分别为19.2%和23.5%，同时受累发生率为27.1%。肾上腺皮质功能减退的发生率为7.1%。靶腺功能减退的总发生率为10.7%。垂体后叶功能减退常在术后发生。对于单纯接受放疗的患者，由于照射剂量较高，下丘脑 - 垂体及靶腺功能减退的发生率较高。激素替代疗法成功治疗了垂体功能减退和靶腺功能减退。对于垂体腺瘤放疗，推荐DT 40 - 45 Gy，照射野4×4 cm。
