Center for Biomedical Research, Population Council, New York, New York 10065, USA.
Curr Opin HIV AIDS. 2011 Sep;6(5):379-84. doi: 10.1097/COH.0b013e3283499d63.
Myeloid dendritic cells (mDCs) are pivotal players in HIV-1 infection. They promote transmission and spread and at the same time are critical for recognizing HIV-1 and initiating immune responses to fight infection. Notably, their immunostimulatory capabilities can be harnessed to design better HIV-1 vaccines. In this review, advances in these areas of mDC-HIV-1 interactions are summarized.
New insights into HIV-1-induced dysfunction of mDCs and dysfunctional mDC effects on other cell types, as well as novel mechanisms of viral sensing by mDCs and their evasion by HIV-1, have been uncovered. These results emphasize the importance of mDCs in protection against HIV-1 infection. Targeting mDCs with vaccines and tailored adjuvants may improve the quality and anatomical location of elicited immune responses.
Understanding the multiplicity of HIV-1-dendritic cell interactions together with the numerous advances in targeted therapy and vaccination will help in the rational design of approaches to treat and block infection.
树突状细胞（mDCs）是 HIV-1 感染的关键参与者。它们促进了病毒的传播和扩散，同时对识别 HIV-1 和启动免疫反应以抵抗感染至关重要。值得注意的是，它们的免疫刺激能力可以被利用来设计更好的 HIV-1 疫苗。在这篇综述中，总结了 mDC 与 HIV-1 相互作用领域的进展。
对 HIV-1 诱导的 mDC 功能障碍以及功能失调的 mDC 对其他细胞类型的影响，以及 mDC 对病毒的感应及其被 HIV-1 逃避的新机制的新见解已经被揭示。这些结果强调了 mDC 在预防 HIV-1 感染中的重要性。用疫苗和针对性的佐剂靶向 mDCs 可能会改善诱导免疫反应的质量和解剖位置。
理解 HIV-1-树突状细胞相互作用的多样性，以及靶向治疗和疫苗接种方面的许多进展，将有助于合理设计治疗和阻断感染的方法。
