HIV-1 感染中的髓样树突状细胞。
Myeloid dendritic cells in HIV-1 infection.
机构信息
Center for Biomedical Research, Population Council, New York, New York 10065, USA.
出版信息
Curr Opin HIV AIDS. 2011 Sep;6(5):379-84. doi: 10.1097/COH.0b013e3283499d63.
Abstract
PURPOSE OF REVIEW
Myeloid dendritic cells (mDCs) are pivotal players in HIV-1 infection. They promote transmission and spread and at the same time are critical for recognizing HIV-1 and initiating immune responses to fight infection. Notably, their immunostimulatory capabilities can be harnessed to design better HIV-1 vaccines. In this review, advances in these areas of mDC-HIV-1 interactions are summarized.
RECENT FINDINGS
New insights into HIV-1-induced dysfunction of mDCs and dysfunctional mDC effects on other cell types, as well as novel mechanisms of viral sensing by mDCs and their evasion by HIV-1, have been uncovered. These results emphasize the importance of mDCs in protection against HIV-1 infection. Targeting mDCs with vaccines and tailored adjuvants may improve the quality and anatomical location of elicited immune responses.
SUMMARY
Understanding the multiplicity of HIV-1-dendritic cell interactions together with the numerous advances in targeted therapy and vaccination will help in the rational design of approaches to treat and block infection.
摘要
目的综述
树突状细胞（mDCs）是 HIV-1 感染的关键参与者。它们促进了病毒的传播和扩散，同时对识别 HIV-1 和启动免疫反应以抵抗感染至关重要。值得注意的是，它们的免疫刺激能力可以被利用来设计更好的 HIV-1 疫苗。在这篇综述中，总结了 mDC 与 HIV-1 相互作用领域的进展。
最近的发现
对 HIV-1 诱导的 mDC 功能障碍以及功能失调的 mDC 对其他细胞类型的影响，以及 mDC 对病毒的感应及其被 HIV-1 逃避的新机制的新见解已经被揭示。这些结果强调了 mDC 在预防 HIV-1 感染中的重要性。用疫苗和针对性的佐剂靶向 mDCs 可能会改善诱导免疫反应的质量和解剖位置。
总结
理解 HIV-1-树突状细胞相互作用的多样性，以及靶向治疗和疫苗接种方面的许多进展，将有助于合理设计治疗和阻断感染的方法。
相似文献
1
Myeloid dendritic cells in HIV-1 infection.HIV-1 感染中的髓样树突状细胞。
Curr Opin HIV AIDS. 2011 Sep;6(5):379-84. doi: 10.1097/COH.0b013e3283499d63.
2
Dendritic cell dysregulation during HIV-1 infection.HIV-1 感染期间树突状细胞的失调。
Immunol Rev. 2013 Jul;254(1):170-89. doi: 10.1111/imr.12082.
3
Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition.血液髓样树突状细胞和浆细胞样树突状细胞在HIV-1感染T细胞中的相反作用：促进传播与抑制复制。
Blood. 2006 Sep 15;108(6):1957-64. doi: 10.1182/blood-2006-03-010918. Epub 2006 May 16.
4
Virus particle release from glycosphingolipid-enriched microdomains is essential for dendritic cell-mediated capture and transfer of HIV-1 and henipavirus.病毒粒子从富含糖脂的微域中的释放对于树突状细胞介导的 HIV-1 和亨德拉尼帕病毒的捕获和转移是至关重要的。
J Virol. 2014 Aug;88(16):8813-25. doi: 10.1128/JVI.00992-14. Epub 2014 May 28.
5
Myeloid Cells Enriched for a Dendritic Cell Population From People Living With HIV Have Altered Gene Expression Not Restored by Antiretroviral Therapy.从 HIV 感染者中富集树突状细胞的髓样细胞具有改变的基因表达，而抗逆转录病毒治疗无法使其恢复正常。
Front Immunol. 2020 Mar 4;11:261. doi: 10.3389/fimmu.2020.00261. eCollection 2020.
6
Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an exploratory study.在一项探索性研究中，HIV-1 感染者的血液髓样树突状细胞表现出促凋亡表型，其特征是 Bcl-2 水平降低和 caspase-3+频率增加，与血浆病毒载量和 T 细胞活化水平相关。
J Virol. 2011 Jan;85(1):397-409. doi: 10.1128/JVI.01118-10. Epub 2010 Oct 20.
7
Chinese human immunodeficiency virus-1 patients with different routes of transmission exhibit altered expression levels of blood dendritic cell subpopulations.中国人类免疫缺陷病毒-1 患者不同传播途径的血液树突状细胞亚群表达水平发生改变。
Viral Immunol. 2011 Feb;24(1):35-43. doi: 10.1089/vim.2010.0038.
8
Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells.成熟树突状细胞中无细胞和细胞相关病毒捕获的动态成像。
Traffic. 2011 Dec;12(12):1702-13. doi: 10.1111/j.1600-0854.2011.01281.x. Epub 2011 Oct 10.
9
Irreversible loss of pDCs by apoptosis during early HIV infection may be a critical determinant of immune dysfunction.在 HIV 感染早期，pDC 细胞通过细胞凋亡发生不可逆转的损失，这可能是免疫功能障碍的一个关键决定因素。
Viral Immunol. 2010 Jun;23(3):241-9. doi: 10.1089/vim.2009.0112.
10
Dendritic-cell interactions with HIV: infection and viral dissemination.树突状细胞与HIV的相互作用：感染与病毒传播
Nat Rev Immunol. 2006 Nov;6(11):859-68. doi: 10.1038/nri1960.
引用本文的文献
1
The causal relationship between immune cells and Sjögren's syndrome: a univariate, multivariate, bidirectional Mendelian randomized study.免疫细胞与干燥综合征之间的因果关系：一项单变量、多变量、双向孟德尔随机化研究。
Front Med (Lausanne). 2024 Jul 2;11:1408562. doi: 10.3389/fmed.2024.1408562. eCollection 2024.
2
FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines.FcRn在DEC205靶向疫苗下游调节树突状细胞中的抗原呈递。
NPJ Vaccines. 2024 Apr 9;9(1):76. doi: 10.1038/s41541-024-00854-8.
3
The Role of Dendritic Cells During Infections Caused by Highly Prevalent Viruses.树突状细胞在高流行病毒感染中的作用。
Front Immunol. 2020 Jul 16;11:1513. doi: 10.3389/fimmu.2020.01513. eCollection 2020.
4
Dendritic Cells, the Double Agent in the War Against HIV-1.树突状细胞，对抗 HIV-1 之战中的双面间谍。
Front Immunol. 2019 Oct 23;10:2485. doi: 10.3389/fimmu.2019.02485. eCollection 2019.
5
The Role of the BCL-2 Family of Proteins in HIV-1 Pathogenesis and Persistence.BCL-2 家族蛋白在 HIV-1 发病机制和持续存在中的作用。
Clin Microbiol Rev. 2019 Oct 30;33(1). doi: 10.1128/CMR.00107-19. Print 2019 Dec 18.
6
Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells.完整人宫颈外植体中的髓系细胞捕获 HIV 并将其传播给 CD4 T 细胞。
Front Immunol. 2018 Nov 23;9:2719. doi: 10.3389/fimmu.2018.02719. eCollection 2018.
7
PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo.聚肌胞苷酸-聚左旋赖氨酸-羧甲基纤维素在体外和体内对树突状细胞- T细胞环境发挥促进和抗HIV作用。
PLoS One. 2016 Sep 7;11(9):e0161730. doi: 10.1371/journal.pone.0161730. eCollection 2016.
8
The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications.低成本复合木质素磺酸（LA）具有广谱抗HIV和抗HSV活性，具有作为杀微生物剂应用的潜力。
PLoS One. 2015 Jul 1;10(7):e0131219. doi: 10.1371/journal.pone.0131219. eCollection 2015.
9
Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection.维甲酸使树突状细胞呈现出黏膜样表型，增强了其促进HIV-1感染的能力。
J Immunol. 2015 Mar 1;194(5):2415-23. doi: 10.4049/jimmunol.1402623. Epub 2015 Jan 26.
10
Accumulation of functionally immature myeloid dendritic cells in lymph nodes of rhesus macaques with acute pathogenic simian immunodeficiency virus infection.急性致病性猴免疫缺陷病毒感染的恒河猴淋巴结中功能不成熟的髓样树突状细胞的积累。
Immunology. 2014 Oct;143(2):146-54. doi: 10.1111/imm.12295.
本文引用的文献
1
HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target.单纯疱疹病毒 2 感染树突状细胞可放大高度易感的 HIV-1 细胞靶标。
PLoS Pathog. 2011 Jun;7(6):e1002109. doi: 10.1371/journal.ppat.1002109. Epub 2011 Jun 30.
2
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.SAMHD1 是树突状细胞和髓样细胞特异性的 HIV-1 限制因子，可被 Vpx 拮抗。
Nature. 2011 May 25;474(7353):654-7. doi: 10.1038/nature10117.
3
Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells.人类免疫缺陷病毒 1 型经改造后能够有效地包装猴免疫缺陷病毒 Vpx 感染巨噬细胞和树突状细胞。
J Virol. 2011 Jul;85(13):6263-74. doi: 10.1128/JVI.00346-11. Epub 2011 Apr 20.
4
HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production.树突状细胞感染 HIV 后通过 IRF-1 抑制 IFN 诱导途径并抑制 1 型 IFN 的产生。
Blood. 2011 Jul 14;118(2):298-308. doi: 10.1182/blood-2010-07-297721. Epub 2011 Mar 16.
5
Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients.HIV-1 感染者中浆细胞样和单核细胞来源的 DC 而非髓样 DC 丧失 NK 刺激能力。
PLoS One. 2011 Mar 8;6(3):e17525. doi: 10.1371/journal.pone.0017525.
6
Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.人乳与病原体受体 DC-SIGN 的结合随胆汁盐刺激的脂肪酶（BSSL）基因多态性而变化。
PLoS One. 2011 Feb 28;6(2):e17316. doi: 10.1371/journal.pone.0017316.
7
The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission.早期传播 HIV gp120 的基因型促进 α (4) β(7)-反应性，揭示 α (4) β(7) +/CD4+ T 细胞是黏膜传播的关键靶标。
PLoS Pathog. 2011 Feb;7(2):e1001301. doi: 10.1371/journal.ppat.1001301. Epub 2011 Feb 24.
8
Innate sensing of HIV-infected cells.先天感知感染 HIV 的细胞。
PLoS Pathog. 2011 Feb;7(2):e1001284. doi: 10.1371/journal.ppat.1001284. Epub 2011 Feb 17.
9
TLR8 activates HIV from latently infected cells of myeloid-monocytic origin directly via the MAPK pathway and from latently infected CD4+ T cells indirectly via TNF-α.TLR8 通过 MAPK 通路直接从髓样单核细胞来源的潜伏感染细胞中激活 HIV，通过 TNF-α 从潜伏感染的 CD4+ T 细胞中间接激活 HIV。
J Immunol. 2011 Apr 1;186(7):4314-24. doi: 10.4049/jimmunol.1003174. Epub 2011 Feb 28.
10
DCs and NK cells: critical effectors in the immune response to HIV-1.树突状细胞和自然杀伤细胞：HIV-1 免疫反应中的关键效应因子。
Nat Rev Immunol. 2011 Mar;11(3):176-86. doi: 10.1038/nri2935.
Zotero 插件