Chernysh A M, Farber F E
Fiziol Zh SSSR Im I M Sechenova. 1990 Jul;76(7):869-74.
In anesthetized dogs, changes of tensions due to the effect of CaCl2 solution were studied in the left ventricle's wall and the heart apex. Hemodynamic parameters, ECG and intramural tension were recorded. The tension forms looked different in the wall and the apex at normal cardiac contractions; they changed in different ways under the effect of inotropic factors. The latters could induce three types of the amplitude non-uniformity in the left ventricle's wall and in the apex, depending on the drug and its dose. The non-uniformity type for a separate heart is specific in respect to administered drug. The non-uniformities at large doses of inotropic factor exceeding normal physiological levels, are regarded as an additional mechanism of the heart stability under considerable loads.
在麻醉犬中,研究了氯化钙溶液作用下左心室壁和心尖部张力的变化。记录了血流动力学参数、心电图和心肌壁内张力。在正常心脏收缩时,壁和心尖部的张力形式不同;在变力因素的作用下,它们以不同方式变化。根据药物及其剂量,这些因素可在左心室壁和心尖部诱发三种类型的幅度不均匀性。对于单个心脏而言,不均匀性类型因所给予的药物而异。大剂量超过正常生理水平的变力因素引起的不均匀性,被视为心脏在相当大负荷下稳定性的一种额外机制。