Ramsey Susan E, Engler Patricia A, Stein Michael D, Brown Richard A, Cioe Patricia, Kahler Christopher W, Promrat Kittichai, Rose Jennifer, Anthony Jennifer, Solomon David A
The Warren Alpert Medical School of Brown University, USA.
J Addict Res Ther. 2011 May 13;2(2):2-10. doi: 10.4172/2155-6105.1000109.
To examine the efficacy of a cognitive-behavioral intervention (CBT) to prevent depression among methadone maintenance patients undergoing antiviral treatment for hepatitis C (HCV), 29 patients beginning HCV treatment were randomized to CBT or standard care (SC). Study participants did not meet criteria for major depressive disorder at the time of study recruitment. CBT did not result in less depression-related antiviral treatment failure, better adherence to antiviral treatment, or better HCV RNA outcomes. There were no significant treatment group differences on depressive symptoms over time. The CBT group did display a greater and more consistent decline in both BDI-II and HAM-D scores over time (d=.85 on the BDI-II; d=.72 on the HAM-D).
为了检验认知行为干预（CBT）对正在接受丙型肝炎（HCV）抗病毒治疗的美沙酮维持治疗患者预防抑郁症的疗效，29名开始接受HCV治疗的患者被随机分为CBT组或标准护理（SC）组。研究参与者在研究招募时不符合重度抑郁症的标准。CBT并没有导致与抑郁症相关的抗病毒治疗失败率降低、对抗病毒治疗的依从性提高或HCV RNA结果更好。随着时间的推移，治疗组在抑郁症状方面没有显著差异。随着时间的推移，CBT组在贝克抑郁量表第二版（BDI-II）和汉密尔顿抑郁量表（HAM-D）上的得分确实出现了更大且更一致的下降（BDI-II上的效应量d = 0.85；HAM-D上的效应量d = 0.72）。
