Winn Virginia D, Gormley Matthew, Fisher Susan J
Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado 80045.
Pregnancy Hypertens. 2011 Jan 1;1(1):100-8. doi: 10.1016/j.preghy.2010.12.001.
Preeclampsia (PE) impacts 8 million mother-infant pairs worldwide each year. This human pregnancy-specific disease characterized by hypertension and proteinuria accounts for significant maternal and neonatal morbidity and mortality. The current theory of the pathogenesis of PE as reviewed by Drs. Christopher Redman and Ian Sargent is thought to occur as a 2-stage process with poor placentation in the first half of pregnancy resulting in the maternal response in the second half of pregnancy. Our studies have focused on understanding the placental contribution to this serious disease by examining the gene expression profile of the deciduas basalis or basal plate, the region of the placenta involved in the "poor placentation". In this review we present summaries of our microarray datasets both of normal placentation and those gene expression changes resulting in the context of PE. Additionally, we have taken this opportunity to combine the data sets to provide a more comprehensive view of this region of the placenta. As defects in the basal plate are, in part, at the root of the disease process, we believe that understanding the pathobiology that occurs in this region will increase our ability to alter the development and/or course of PE.
子痫前期（PE）每年影响全球800万母婴。这种以高血压和蛋白尿为特征的人类妊娠期特有疾病导致了严重的孕产妇和新生儿发病及死亡。克里斯托弗·雷德曼博士和伊恩·萨金特博士综述的当前PE发病机制理论认为，其发生过程分为两个阶段，妊娠前半期胎盘形成不良，导致妊娠后半期母体产生反应。我们的研究重点是通过检查基蜕膜或基底板（胎盘参与“胎盘形成不良”的区域）的基因表达谱，来了解胎盘对这种严重疾病的影响。在这篇综述中，我们展示了正常胎盘形成以及PE情况下基因表达变化的微阵列数据集摘要。此外，我们借此机会合并数据集，以更全面地了解胎盘的这个区域。由于基底板的缺陷部分是疾病过程的根源，我们相信了解该区域发生的病理生物学将提高我们改变PE发展和/或病程的能力。
