Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655, Japan.
J Bone Miner Metab. 2011 Nov;29(6):699-708. doi: 10.1007/s00774-011-0266-8. Epub 2011 Apr 6.
We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40-79 years; 50 of each gender and age stratum) from a list of registered residents in 1993. We measured BMD of the spine and hip, and serum concentrations of total osteocalcin (OC), beta-C-terminal cross-linking telopeptide of type I collagen (beta-CTX), and N-terminal cross-linking telopeptide of type I collagen (NTX), in 1993 and 2003. Of the 400 subjects, 322 (153 men, 169 women) completed the 10-year follow-up. Mean change rates (standard deviation) for serum total OC, beta-CTX, and NTX over 10 years were -1.00 (3.74)%/year, 5.10 (22.48)%/year, and 0.40 (3.41)%/year, respectively, in men, and 0.02 (5.32)%/year, 5.53 (14.54)%/year, and 0.62 (3.26)%/year, respectively, in women. Change rates of BTMs were higher for women in their forties than for women in their fifties to seventies (P < 0.05), and higher in the menstrual transition group than in pre- and postmenopausal groups (P < 0.001). Changes in levels of BTMs over 10 years in women were significantly associated with change rates of BMDs at L2-L4 and total hip after adjusting for potential confounders. A significant birth-cohort effect was observed among women in their fifties. We concluded that change rates of BTMs during the 10 years were influenced by menstrual transition, age, and sex and associated with bone loss at L2-L4 and total hip.
我们旨在阐明日本社区中骨转换生化标志物（BTMs）在 10 年内的变化，这些变化与骨密度（BMD）变化的关系，以及出生队列效应。我们从 1993 年的注册居民名单中随机选择了 400 名个体（年龄 40-79 岁；每个性别和年龄组各 50 名）。我们在 1993 年和 2003 年测量了脊柱和臀部的 BMD，以及血清总骨钙素（OC）、I 型胶原β-C 端交联肽（β-CTX）和 I 型胶原 N 端交联肽（NTX）的浓度。在 400 名受试者中，322 名（153 名男性，169 名女性）完成了 10 年的随访。男性血清总 OC、β-CTX 和 NTX 在 10 年内的平均变化率（标准差）分别为-1.00（3.74）%/年、5.10（22.48）%/年和 0.40（3.41）%/年，女性分别为 0.02（5.32）%/年、5.53（14.54）%/年和 0.62（3.26）%/年。四十多岁的女性 BTM 变化率高于五十多岁到七十多岁的女性（P<0.05），月经过渡期组高于绝经前和绝经后组（P<0.001）。调整潜在混杂因素后，女性 10 年内 BTM 水平的变化与 L2-L4 和全髋 BMD 变化率显著相关。五十多岁女性中存在显著的出生队列效应。我们得出结论，在 10 年内 BTM 的变化率受到月经过渡期、年龄和性别影响，并与 L2-L4 和全髋的骨丢失相关。
