爱泼斯坦-巴尔病毒编码蛋白及B细胞标志物在致死性传染性单核细胞增多症中的表达

Expression of Epstein-Barr virus-encoded proteins and B-cell markers in fatal infectious mononucleosis.

作者信息

Falk K, Ernberg I, Sakthivel R, Davis J, Christensson B, Luka J, Okano M, Grierson H L, Klein G, Purtilo D T

机构信息

Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.

出版信息

Int J Cancer. 1990 Dec 15;46(6):976-84. doi: 10.1002/ijc.2910460605.

DOI:10.1002/ijc.2910460605

PMID:2174416

Abstract

We assessed 33 lymphoid tissues from 15 patients, including 7 with X-linked lymphoproliferative disease (XLP) and 8 patients with sporadic fatal infectious mononucleosis (IM), to determine whether the cellular infiltrate had the immunophenotype and expressed Epstein-Barr virus (EBV)-encoded proteins characteristic of either EBV-immortalized lymphoblastoid cell lines (LCL) or EBV-carrying Burkitt lymphoma (BL) cells. The results of these studies revealed that in 13 cases the proliferating B cells were polyclonal, LCL-like, and in 2 cases they were monoclonal, malignant lymphoma-like.

摘要

我们评估了15例患者的33个淋巴组织，其中包括7例X连锁淋巴增殖性疾病（XLP）患者和8例散发性致命传染性单核细胞增多症（IM）患者，以确定细胞浸润是否具有免疫表型，并表达爱泼斯坦-巴尔病毒（EBV）编码的蛋白，这些蛋白是EBV永生化淋巴母细胞系（LCL）或携带EBV的伯基特淋巴瘤（BL）细胞所特有的。这些研究结果显示，在13例病例中，增殖的B细胞是多克隆的、LCL样的，在2例病例中，它们是单克隆的、恶性淋巴瘤样的。