Department of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou City, Guangdong Province, PR China.
J Surg Oncol. 2011 Nov 1;104(6):617-22. doi: 10.1002/jso.22018. Epub 2011 Jul 8.
Rad51 plays a critical role in homologous recombination and correlates with many human malignancies. However, its role and clinical significance in esophageal squamous cell carcinoma (ESCC) has not been clarified. The purpose of this study was to explore the clinicopathological correlation and prognostic significance of Rad51 expression in a group of ESCC patients.
We evaluated Rad51 expression in 230 surgically resected ESCC specimens by immunochemistry using tissue microarray and correlated with clinicopathological features including post-operation survival.
There was no significant correlation between Rad51 expression and clinicopathological characteristics in terms of age, sex, tumor location, histologic grade, T, N categories, and TNM stage. The Kaplan-Meier survival analysis showed that high expression of Rad51 indicated a poorer disease free survival (DFS) of ESCC patients compared with the patients with low expression of Rad51 (P = 0.031), similar result also shown in overall survival (OS) analysis (P = 0.034). Furthermore, Rad51 expression could stratify node positive patients in DFS (P = 0.021) and OS (P = 0.035). Multivariate analysis confirmed the Rad51 expression was an independent prognostic factor for DFS (HR = 1.603, P = 0.013) and OS (HR = 1.555, P = 0.021) of ESCC patients.
Elevated expression of Rad51 is associated with poor prognosis for resectable ESCC patients.
Rad51 在同源重组中起着关键作用，与许多人类恶性肿瘤相关。然而，其在食管鳞状细胞癌（ESCC）中的作用和临床意义尚未阐明。本研究旨在探讨一组 ESCC 患者中 Rad51 表达的临床病理相关性和预后意义。
我们使用组织微阵列免疫化学法评估了 230 例手术切除的 ESCC 标本中的 Rad51 表达，并将其与包括术后生存在内的临床病理特征相关联。
Rad51 表达与年龄、性别、肿瘤部位、组织学分级、T、N 分期和 TNM 分期等临床病理特征之间无显著相关性。Kaplan-Meier 生存分析显示，Rad51 高表达的 ESCC 患者无病生存（DFS）较差，与 Rad51 低表达的患者相比（P=0.031），总生存（OS）分析也显示出类似的结果（P=0.034）。此外，Rad51 表达可分层阳性淋巴结患者的 DFS（P=0.021）和 OS（P=0.035）。多变量分析证实 Rad51 表达是 ESCC 患者 DFS（HR=1.603，P=0.013）和 OS（HR=1.555，P=0.021）的独立预后因素。
Rad51 的高表达与可切除的 ESCC 患者的不良预后相关。
