EPSRC National Mass Spectrometry Service Centre (NMSSC), Institute of Mass Spectrometry (IMS), College of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
J Mass Spectrom. 2011 Jul;46(7):712-9. doi: 10.1002/jms.1957.
A mini-review of the characterisation of metal-containing compounds by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOFMS) is presented. Organometallic and coordination compounds have many varied applications, most notably in industrial catalytic processes and also in the electronics and healthcare sectors. In general, the compounds discussed, be they small or large molecules, have a high percentage metal content, rather than simply containing 'a metal atom'. A brief history of the field is given, but the main scope over the last 5 years is covered in some detail. How MALDI-TOFMS compliments electrospray for metal-containing compounds is highlighted. Perspectives on recent advances, such as solvent-free and air/moisture-sensitive sample preparation, and potential future challenges and developments, such as nanomaterials and metallodrug/metallometabolite imaging, are given.
本文对基质辅助激光解吸/电离飞行时间质谱（MALDI-TOFMS）分析含金属化合物的特性进行了综述。有机金属和配位化合物具有许多不同的应用，特别是在工业催化过程中，以及在电子和医疗保健领域。一般来说，所讨论的化合物，无论是小分子还是大分子，都具有高百分比的金属含量，而不仅仅是含有“一个金属原子”。本文简要介绍了该领域的历史，但主要涵盖了过去 5 年的详细内容。突出了 MALDI-TOFMS 如何补充用于含金属化合物的电喷雾技术。本文还介绍了该领域的最新进展，如无溶剂和空气/湿度敏感样品制备，以及潜在的未来挑战和发展，如纳米材料和金属药物/金属代谢物成像。
