Mineura K, Sasajima T, Sakamoto T, Kowada M
Neurosurgical Service, Akita Univ. Hospital.
Gan No Rinsho. 1990 Nov;36(14):2399-403.
Presented is a retrospective study of 20 patients with intracranial germ cell tumors who the authors have treated during past 10 years. The cases among these patients included thirteen germinomas, three teratomas, two embryonal carcinomas, and two malignant teratomas. A ventriculoperitoneal shunt was installed in 15 cass and the tumor was surgically removed in four cases. All cases were irradiated with 33 to 61 Gy; in 18 cases, more than half of the total dose was delivered to the whole brain, and in 9 cases, spinal irradiation was given because of a verified CSF dissemination. Chemotherapy was the regimen for four cases. The tumor responded to therapy in 16 (84%) of 19 evaluable cases. Overall, the median and five year survival were 102 months and 83%, respectively. The survival rate was found to vary between the benign group (germinoma, teratoma) and the malignant group (embryonal carcinoma, malignant teratoma, germinoma with STGC) (p less than 0.01).
本文呈现了一项对20例颅内生殖细胞肿瘤患者的回顾性研究，这些患者是作者在过去10年中治疗的。这些患者中的病例包括13例生殖细胞瘤、3例畸胎瘤、2例胚胎癌和2例恶性畸胎瘤。15例患者安装了脑室腹腔分流术，4例患者进行了肿瘤手术切除。所有病例均接受了33至61 Gy的照射；18例患者中，总剂量的一半以上照射全脑，9例患者因证实脑脊液播散而接受脊髓照射。4例患者采用化疗方案。19例可评估病例中有16例（84%）对治疗有反应。总体而言，中位生存期和5年生存率分别为102个月和83%。发现良性组（生殖细胞瘤、畸胎瘤）和恶性组（胚胎癌、恶性畸胎瘤、伴有STGC的生殖细胞瘤）的生存率有所不同（p小于0.01）。
