Chen Kinon, Weiland James D
Department of Biomedical Engineering, University of Southern California, Denney Research Center 140, 1042 Downey Way, Los Angeles, CA 90089, USA.
J Biomech Eng. 2011 Jun;133(6):064505. doi: 10.1115/1.4004289.
There is an increasing need to understand the mechanical properties of human orbital fat and its encapsulating connective tissue (OFCT), but such knowledge is not available in the current literature. The purpose of the present study is to examine the mechanical properties of the OFCT. From 5 pairs of 76- to 92-year-old Caucasian human eyes and 33 5- to 7-month-old porcine eyes, 5 human and 11 porcine OFCT samples were dissected at the posterior pole or adjacent to the pole in the vertical, horizontal, and radial directions. Sample dimensions were fixed or measured. Tensile tests were performed on the samples in body-temperature saline. The stress-strain relationship was first approximately linear and then became nonlinear. The linear, the neo-Hookean, and the Mooney-Rivlin constants are reported in Tables 1 and 2. No statistical difference was found among their properties in the different directions in either the human or the porcine samples. Statistical differences were found between the human and the porcine material constants in the horizontal and radial directions. Among our material models, only the Mooney-Rivlin model was able to capture the mechanical properties of the OFCT in large deformation properly. The Mooney-Rivlin model was especially adaptive to the human data. This is the first time the mechanical properties of the human and porcine OFCT have been examined in the literature. We believe our data will provide valuable information to others regarding designing implant biomaterials in orbital treatments and developing computer models to study orbital biomechanics.
人们越来越需要了解人类眼眶脂肪及其包裹性结缔组织（OFCT）的力学性能，但目前的文献中尚无此类知识。本研究的目的是研究OFCT的力学性能。从5对76至92岁的白种人眼睛和33只5至7个月大的猪眼睛中，在垂直、水平和径向方向的后极或极点附近解剖出5个人类和11个猪的OFCT样本。固定或测量样本尺寸。在体温盐水中对样本进行拉伸试验。应力-应变关系首先大致呈线性，然后变为非线性。表1和表2报告了线性、新胡克和穆尼-里夫林常数。在人类或猪的样本中，不同方向的性能之间未发现统计学差异。在水平和径向方向上，人类和猪的材料常数之间存在统计学差异。在我们的材料模型中，只有穆尼-里夫林模型能够正确捕捉OFCT在大变形时的力学性能。穆尼-里夫林模型特别适用于人类数据。这是首次在文献中研究人类和猪的OFCT的力学性能。我们相信我们的数据将为其他人在眼眶治疗中设计植入生物材料以及开发研究眼眶生物力学的计算机模型提供有价值的信息。
