Makarem Ahmed, Abass Ahmed, Bao Fangjun, Elsheikh Ahmed
School of Engineering, University of Liverpool, Liverpool, United Kingdom.
Faculty of Engineering, Port Said University, Port Fouad, Egypt.
Front Bioeng Biotechnol. 2023 Jul 10;11:1146828. doi: 10.3389/fbioe.2023.1146828. eCollection 2023.
To estimate the material stiffness of the orbital soft tissue in human orbits using an inverse numerical analysis approach, which could be used in future studies to understand the behaviour under dynamic, non-contact tonometry or simulate various ophthalmological conditions. Clinical data were obtained for the left eye of 185 Chinese participants subjected to a complete ophthalmic examination, including tests by the Corvis ST and Pentacam. 185 numerical models of the eye globes were built with idealised geometry of the sclera while considering the corneal tomography measured by the Pentacam. The models were extended to include representations of the orbital soft tissue (OST), which were given idealised geometry. The movement of the whole eye in response to an air-puff directed at the central cornea was examined and used in an inverse analysis process to estimate the biomechanical stiffness parameters of the OST. The results indicated a weak correlation of with the progression of age, regardless of the stress at which was calculated. However, there was evidence of significant differences in between some of the age groups. There was statistical evidence of significant differences between in the age range 20< < 43 relative to in OST with age ranges 43< < 63 ( = 0.022) and 63< < 91 ( = 0.011). In contrast, in OST with age ranges 43< < 63 and 63< < 91 were not significantly different ( = 0.863). The optimised mechanical properties of the OST were found to be almost four times stiffer than properties of fatty tissue of previous experimental work. This study consolidated previous findings of the role of extraocular muscles on the ocular suppor system. In addition, the rotation of the globe during corvis loading is suggested to be of posterior components of the globe and shall be further investigated.
使用逆数值分析方法估计人类眼眶内眼眶软组织的材料刚度，该方法可用于未来的研究，以了解动态、非接触眼压测量下的行为或模拟各种眼科疾病。获取了185名接受全面眼科检查的中国参与者左眼的临床数据，包括Corvis ST和Pentacam检查。在考虑Pentacam测量的角膜断层扫描的同时，构建了185个具有理想化巩膜几何形状的眼球数值模型。这些模型被扩展以包括眼眶软组织（OST）的表示，其具有理想化的几何形状。研究了整个眼睛对指向中央角膜的气流的运动，并将其用于逆分析过程中，以估计OST的生物力学刚度参数。结果表明，无论计算应力时的情况如何， 与年龄进展之间的相关性较弱。然而，有证据表明某些年龄组之间在 方面存在显著差异。有统计证据表明，年龄范围在20< < 43的 与年龄范围在43< < 63（ = 0.022）和63< < 91（ = 0.011）的OST中的 之间存在显著差异。相比之下，年龄范围在43< < 63和63< < 91的OST中的 没有显著差异（ = 0.863）。发现OST的优化力学性能几乎比先前实验工作中脂肪组织的性能硬四倍。本研究巩固了先前关于眼外肌在眼支持系统中作用的发现。此外，建议在Corvis加载期间眼球的旋转是眼球后部组件的旋转，应进一步研究。
