Gerosa Clara, Fanos Vassilios, Fanni Daniela, Nemolato Sonia, Locci Annalisa, Xanthos Theodoros, Papalois Apostolos, Faa Gavino, Iacovidou Nicoletta
Department of Pathology, NICU, University of Cagliari, Cagliari, Italy.
J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 2:52-4. doi: 10.3109/14767058.2011.602923.
Significant differences regarding nephrogenesis and its completion among different animal species have been reported. Since many informations on clinical conditions (i.e. asphyxia, drugs) are extrapolated from piglets, this study aimed at analyzing nephrogenesis in piglets, in order to compare it with existing data on nephrogenesis in humans.
Six male newborn piglets were subjected to euthanasia and their kidneys were harvested. Necropsy revealed no injury and no underlying pathology in any of the animals used in the experiment.
The analysis of the renal cortex evidenced in all the animals studied the presence of active nephrogenesis. The sequence of events identified during porcine nephrogenesis was characterized by the appearance, in the metanephric mesenchyme, of nodules undergoing mesenchymal-epithelial transition originating a specific picture that we named the tubulo-glomerular nodule. This peculiar developmental structure gives rise to the precursor of tubular and glomerular structures, till the extrusion of developing glomeruli that progressively migrate toward the mid and deep cortex.
Nephrogenesis in pig is characterized by a peculiar morphological event, with marked differences compared with humans. These informations should be taken into account when the experimental data in piglets are extrapolated to humans, especially for clinical purposes.
据报道，不同动物物种在肾发生及其完成过程中存在显著差异。由于许多关于临床情况（如窒息、药物）的信息是从仔猪推断而来的，本研究旨在分析仔猪的肾发生，以便将其与人类肾发生的现有数据进行比较。
对六只雄性新生仔猪实施安乐死并摘取其肾脏。尸检显示，实验中使用的任何动物均无损伤且无潜在病理状况。
对所有研究动物的肾皮质分析表明存在活跃的肾发生。在猪肾发生过程中确定的事件顺序的特征是，在中肾间充质中出现经历间充质 - 上皮转化的结节，形成一种特定的形态，我们将其命名为肾小管 - 肾小球结节。这种独特的发育结构产生肾小管和肾小球结构的前体，直到发育中的肾小球逐渐向皮质中部和深部迁移并挤出。
猪的肾发生具有独特的形态学事件特征，与人类相比存在显著差异。当将仔猪的实验数据外推至人类时，尤其是用于临床目的时，应考虑这些信息。
