精神分裂症患者的海马中间神经元异常。
Hippocampal interneurons are abnormal in schizophrenia.
机构信息
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-8548, USA.
出版信息
Schizophr Res. 2011 Sep;131(1-3):165-73. doi: 10.1016/j.schres.2011.06.007. Epub 2011 Jul 13.
OBJECTIVE
The cellular substrate of hippocampal dysfunction in schizophrenia remains unknown. We tested the hypothesis that hippocampal interneurons are abnormal in schizophrenia, but that the total number of hippocampal neurons in the pyramidal cell layer is normal.
METHODS
We collected whole hippocampal specimens of 13 subjects with schizophrenia and 20 matched healthy control subjects to study the number of all neurons, the somal volume of neurons, the number of somatostatin- and parvalbumin-positive interneurons and the messenger RNA levels of somatostatin, parvalbumin and glutamic acid decarboxylase 67.
RESULTS
The total number of hippocampal neurons in the pyramidal cell layer was normal in schizophrenia, but the number of somatostatin- and parvalbumin-positive interneurons, and the level of somatostatin, parvalbumin and glutamic acid decarboxylase mRNA expression were reduced.
CONCLUSIONS
The study provides strong evidence for a specific defect of hippocampal interneurons in schizophrenia and has implications for emerging models of hippocampal dysfunction in schizophrenia.
目的
精神分裂症中海马功能障碍的细胞基础仍不清楚。我们检验了以下假说，即精神分裂症中海马中间神经元异常，但锥体细胞层中海马神经元的总数是正常的。
方法
我们收集了 13 名精神分裂症患者和 20 名匹配的健康对照者的整个海马标本，以研究所有神经元的数量、神经元的胞体体积、生长抑素和钙结合蛋白阳性中间神经元的数量以及生长抑素、钙结合蛋白和谷氨酸脱羧酶 67 的信使 RNA 水平。
结果
精神分裂症患者的锥体细胞层中海马神经元总数正常，但生长抑素和钙结合蛋白阳性中间神经元的数量以及生长抑素、钙结合蛋白和谷氨酸脱羧酶 mRNA 表达水平降低。
结论
该研究为精神分裂症中海马中间神经元的特定缺陷提供了有力证据，并对精神分裂症中海马功能障碍的新兴模型具有启示意义。
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