Neuroscience Program for Undergraduates, Vanderbilt University, Nashville, TN, USA.
Acta Neuropathol. 2011 Nov;122(5):615-26. doi: 10.1007/s00401-011-0881-4. Epub 2011 Oct 4.
GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.
GABA 能中间神经元同步网络活动并监测信息流。尸检研究报告称，精神分裂症（SZ）和双相情感障碍（BPD）患者皮质中间神经元密度降低。内嗅皮层（EC）及其相邻的海马旁回区域是整合海马和皮质信息的枢纽，这一过程在 SZ 中受到干扰。在这里，我们对比并比较了 BPD 型 I（BPD-I）、SZ 和正常对照（NC）受试者的 EC 尾部和海马旁回区域中间神经元群体的密度。使用 13 名 BPD-I、11 名 SZ 和 17 名 NC 受试者的死后人类海马旁标本，检查了 parvalbumin、somatostatin 或 calbindin 阳性中间神经元的数量密度。我们观察到 BPD-I 和 SZ 中 EC 尾部和旁海马旁回的 parvalbumin 和 somatostatin 阳性中间神经元数量密度降低，但在海马旁回没有变化。在所有检查的脑区，calbindin 阳性中间神经元密度正常。密度降低的情况在 BPD-I 和 SZ 中非常相似。我们的结果表明，BPD-I 和 SZ 中海马旁回区域的 parvalbumin 和 somatostatin 阳性中间神经元密度明显降低，可能破坏皮质-海马回路的同步和整合。
