通过用PhoE-口蹄疫病毒杂交蛋白免疫豚鼠来预防口蹄疫病毒
Protection of guinea-pigs against foot-and-mouth disease virus by immunization with a PhoE-FMDV hybrid protein.
作者信息
Agterberg M, Adriaanse H, Barteling S, van Maanen K, Tommassen J
机构信息
Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, The Netherlands.
出版信息
Vaccine. 1990 Oct;8(5):438-40. doi: 10.1016/0264-410x(90)90242-e.
PMID:2174595
Abstract
A hybrid protein was constructed containing two antigenic determinants of the structural protein VP1 of foot-and-mouth disease virus, inserted in a cell surface-exposed region of Escherichia coli outer membrane protein PhoE. Immunization of guinea-pigs with partially purified protein resulted in high levels of neutralizing antibodies and complete protection against challenge with the virus.
摘要
构建了一种杂合蛋白，其包含口蹄疫病毒结构蛋白VP1的两个抗原决定簇，插入到大肠杆菌外膜蛋白PhoE的细胞表面暴露区域。用部分纯化的蛋白免疫豚鼠可产生高水平的中和抗体，并对病毒攻击提供完全保护。
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