编码麻疹病毒融合蛋白的鸡痘病毒重组体：保护小鼠免受致命性麻疹脑炎侵害
Fowlpox virus recombinant encoding the measles virus fusion protein: protection of mice against fatal measles encephalitis.
作者信息
Wild F, Giraudon P, Spehner D, Drillien R, Lecocq J P
机构信息
Immuno-Virologie Moléculaire et Cellulaire CNRS, Université Claude Bernard Lyon I, France.
出版信息
Vaccine. 1990 Oct;8(5):441-2. doi: 10.1016/0264-410x(90)90243-f.
PMID:2174596
Abstract
A recombinant Fowlpox virus engineered to encode the measles virus fusion protein was shown to protect mice against a challenge measles infection. A vaccine dose of about 10(6) p.f.u. was needed to protect nearly 100% of the animals. Mice failed to develop a significant level of antibodies directed against measles virus suggesting that other components of the immune system may be involved.
摘要
一种经过基因工程改造以编码麻疹病毒融合蛋白的重组鸡痘病毒，已被证明能保护小鼠免受麻疹病毒感染的挑战。需要约10⁶ 个蚀斑形成单位（p.f.u.）的疫苗剂量才能保护近100%的动物。小鼠未能产生针对麻疹病毒的显著水平抗体，这表明免疫系统的其他成分可能参与其中。
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