开发一种双重组疫苗以保护小型反刍动物免受小反刍兽疫病毒和山羊痘病毒感染。
Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections.
作者信息
Berhe G, Minet C, Le Goff C, Barrett T, Ngangnou A, Grillet C, Libeau G, Fleming M, Black D N, Diallo A
机构信息
Cirad, Programme Santé Animale, Campus International de Baillarguet, 34398 Montpellier Cedex 05, France.
出版信息
J Virol. 2003 Jan;77(2):1571-7. doi: 10.1128/jvi.77.2.1571-1577.2003.
Abstract
A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.
摘要
构建了一种含有小反刍兽疫病毒（PPRV）融合蛋白基因cDNA的重组山羊痘病毒疫苗。采用快速高效的方法筛选出高度纯化的重组病毒克隆。一项试验表明，低至0.1 PFU剂量的这种重组疫苗就能保护山羊免受强毒PPRV毒株的攻击。
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