Division of Neonatology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Pediatrics. 2011 Aug;128(2):331-4. doi: 10.1542/peds.2010-3712. Epub 2011 Jul 11.
To assess whether blood transfusions for infants with birth weights of 1000 g or less are a source of mercury and whether any mercury delivered through the transfusion is above the currently set oral reference dose.
We studied an observational cohort. Inclusion criteria included birth weight 1000 g or less and receipt of 1 or more packed red blood cell transfusions. Packed red blood cell units were tested prospectively for mercury levels. The quantity of transfused mercury was calculated on the basis of transfused volume and packed red blood cell mercury level. The resulting mercury level was compared with the reference dose as set by the Agency for Toxic Substances and Disease Registry, the World Health Organization, and the US Environmental Protection Agency.
Thirty-seven infants (birth weight: 736 ± 157 g; gestational age: 25.5 ± 1.5 weeks) met the inclusion criteria. A total of 325 transfusions from 49 packed red blood cell units were administered. Mercury was detected in 40 units. The average mercury level in a packed red blood cell unit was 1.9 ± 2.6 μg/L (median: 0.9 μg/L [interquartile range: 0.3-2.5]). None of the infants received any mercury above the reference dose set by the Agency for Toxic Substances and Disease Registry and the World Health Organization. Twelve infants received 1 transfusion, and 5 infants received 2 transfusions above the Environmental Protection Agency reference dose during their entire hospitalization.
Packed red blood cells are a source of mercury for infants. However, the amount delivered is low compared with currently set safety levels. The episodes in which mercury intake exceeded the reference dose were rare. However, without long-term follow-up, no conclusions can be made about the cognitive implications of these episodes.
评估出生体重为 1000 克或以下的婴儿输血是否为汞的来源，以及通过输血输送的任何汞是否超过目前设定的口服参考剂量。
我们研究了一个观察性队列。纳入标准包括出生体重 1000 克或以下，且接受过 1 次或多次红细胞悬液输血。前瞻性检测红细胞悬液单位的汞含量。根据输注量和红细胞悬液汞含量计算输注的汞量。将所得的汞含量与由毒物和疾病登记署、世界卫生组织和美国环境保护署设定的参考剂量进行比较。
37 名婴儿（出生体重：736±157 克；胎龄：25.5±1.5 周）符合纳入标准。共给予 325 次输血，来自 49 个红细胞悬液单位。40 个单位检测到汞。每个红细胞悬液单位的平均汞含量为 1.9±2.6μg/L（中位数：0.9μg/L[四分位间距：0.3-2.5]）。没有婴儿接受任何超过毒物和疾病登记署和世界卫生组织设定的参考剂量的汞。12 名婴儿接受了 1 次输血，5 名婴儿在整个住院期间接受了 2 次超过环境保护署参考剂量的输血。
红细胞悬液是婴儿汞的来源。然而，与目前设定的安全水平相比，输送的量较低。摄入汞超过参考剂量的情况很少见。然而，由于没有长期随访，因此无法对这些事件对认知的影响得出任何结论。
