电压门控钙通道。
Voltage-gated calcium channels.
机构信息
Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
出版信息
Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
Abstract
Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction. The Ca(V)1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The Ca(V)2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The Ca(V)3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons. This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties.
摘要
电压门控钙 (Ca(2+)) 通道是细胞膜电位变化转化为细胞内 Ca(2+) 瞬变的关键转导器，引发许多生理事件。哺乳动物中有十种电压门控 Ca(2+) 通道家族成员，它们在细胞信号转导中发挥着不同的作用。Ca(V)1 亚家族启动收缩、分泌、基因表达调控、神经元中突触输入的整合以及特殊感觉细胞中 ribbon 突触的传递。Ca(V)2 亚家族主要负责快速突触传递的启动。Ca(V)3 亚家族对于心脏肌细胞和丘脑神经元等节律性放电细胞中动作电位的重复发放很重要。本文介绍了这些 Ca(2+) 通道蛋白的分子关系和生理功能，并提供了它们的分子、遗传、生理和药理学特性信息。
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