Longnecker D S, Kuhlmann E T, Freeman D H
Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03756.
Cancer Res. 1990 Dec 1;50(23):7552-4.
Elastase 1-simian virus transgenic mice, strain Tg(Ela-1, SV40E) Bri18, were studied to characterize the development of pancreatic neoplasms. The incidence of pancreatic carcinomas was compared in groups of male and female mice fed one of three diets chosen because of their effect on the development of pancreatic carcinomas in other animal models. Male mice developed more exocrine carcinomas than female mice and their tumors were larger. Groups fed chow had fewer exocrine carcinomas than groups fed purified diets. The level of fat in the latter diets, 5 versus 20% corn oil, did not alter tumor incidence. An unexpectedly high incidence of islet cell tumors was found in all dietary groups, with a higher incidence in females than in males.
对弹性蛋白酶1-猿猴病毒转基因小鼠（Tg(Ela-1, SV40E) Bri18品系）进行研究，以表征胰腺肿瘤的发展情况。在雄性和雌性小鼠组中比较胰腺癌的发病率，这些小鼠组喂食三种饮食中的一种，选择这三种饮食是因为它们在其他动物模型中对胰腺癌发展的影响。雄性小鼠发生的外分泌癌比雌性小鼠多，且它们的肿瘤更大。喂食普通饲料的组比喂食纯化饲料的组外分泌癌更少。后一种饲料中的脂肪水平（5%与20%玉米油）并未改变肿瘤发病率。在所有饮食组中均发现胰岛细胞瘤的发病率出乎意料地高，雌性的发病率高于雄性。
