Department of Physical Medicine and Rehabilitation, Gülhane Military Medical Academy, Turkish Armed Forces Rehabilitation Center, Ankara, Turkey.
Spinal Cord. 2012 Jun;50(6):472-3. doi: 10.1038/sc.2011.79. Epub 2011 Jul 12.
Case report.
To report a case of paraplegia with limb edema caused by pregabalin.
Turkish Armed Forces Rehabilitation Center, Ankara, Turkey.
A 40-year-old male patient with T11 paraplegia had the complaint of swelling in both the lower limbs. He had been given pregabalin because of the neuropathic pain in both the lower limbs. At 10 months, the patient has experienced edema in lower limbs. There was severe edema in both legs, ankles and feet, more evident on the left. Venous Doppler ultrasound was normal on both sides. Blood tests for possible etiologies were normal. No other etiology could be found. The edema was considered to be caused by pregabalin and the medicine was ceased gradually. The edema resolved completely in 2 weeks.
Pregabalin, which is one of medications used for neuropathic pain, might cause limb edema, that is, a condition needs differential diagnosis. This is particularly important for patients with spinal cord injuries (SCIs). Such adverse effect of pregabalin should be kept in mind as an etiology of limb edema in SCI management.
病例报告。
报告一例因普瑞巴林引起的截瘫伴肢体水肿的病例。
土耳其武装部队康复中心，安卡拉，土耳其。
一名 40 岁男性 T11 截瘫患者出现双下肢肿胀的症状。由于双下肢的神经性疼痛，他曾接受普瑞巴林治疗。在第 10 个月时，患者出现了下肢水肿。双腿、脚踝和脚部都有严重的水肿，左侧更为明显。双侧下肢静脉多普勒超声正常。为寻找可能的病因进行了血液检查，结果正常。未发现其他病因。水肿被认为是由普瑞巴林引起的，逐渐停止使用该药。2 周后水肿完全消退。
普瑞巴林是一种用于治疗神经性疼痛的药物，可能会引起肢体水肿，这是一种需要鉴别诊断的疾病。对于脊髓损伤（SCI）患者尤其重要。在 SCI 管理中，应将普瑞巴林的这种不良反应作为肢体水肿的病因之一加以考虑。
