Grasis Juris A, Tsoukas Constantine D
Department of Biology, San Diego State University, San Diego, CA 92182-4614, USA.
J Signal Transduct. 2011;2011:297868. doi: 10.1155/2011/297868. Epub 2011 Apr 7.
The nonreceptor tyrosine kinase Itk plays a key role in TCR-initiated signaling that directly and significantly affects the regulation of PLCγ1 and the consequent mobilization of Ca(2+). Itk also participates in the regulation of cytoskeletal reorganization as well as cellular adhesion, which is necessary for a productive T cell response. The functional cellular outcome of these molecular regulations by Itk renders it an important mediator of T cell development and differentiation. This paper encompasses the structure of Itk, the signaling parameters leading to Itk activation, and Itk effects on molecular pathways resulting in functional cellular outcomes. The incorporation of these factors persuades one to believe that Itk serves as a modulator, or rheostat, critically fine-tuning the T cell response.
非受体酪氨酸激酶Itk在T细胞受体启动的信号传导中起关键作用，直接且显著地影响磷脂酶Cγ1（PLCγ1）的调节以及随后的钙离子（Ca(2+)）动员。Itk还参与细胞骨架重组以及细胞黏附的调节，而这对于有效的T细胞反应是必需的。Itk对这些分子调节的功能性细胞结果使其成为T细胞发育和分化的重要介质。本文涵盖了Itk的结构、导致Itk激活的信号参数，以及Itk对导致功能性细胞结果的分子途径的影响。这些因素的综合作用使人相信，Itk作为一种调节剂或变阻器，对T细胞反应进行着至关重要的微调。
