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在东亚患者中,全髋关节置换术后深静脉血栓形成和肺栓塞并不常见。

Deep venous thrombosis and pulmonary embolism are uncommon in East Asian patients after total hip arthroplasty.

机构信息

Department of Orthopaedic Surgery, SM Christianity Hospital, Gyeongbuk, South Korea.

出版信息

Clin Orthop Relat Res. 2011 Dec;469(12):3423-8. doi: 10.1007/s11999-011-1979-7. Epub 2011 Jul 12.

Abstract

BACKGROUND

In Western countries, deep vein thrombosis (DVT) and pulmonary embolism (PE), are relatively common after THA and many surgeons recommend routine pharmacologic thromboprophylaxis. There is some suggestion in the literature that the incidences of DVT and PE may be lower in East Asian patients. Therefore, it would be important to establish the incidences in a large number of East Asian patients who did not receive pharmacologic thromboprophylaxis.

PURPOSE

We therefore determined the incidence of DVT and PE and evaluated the associated risk factors in a series of East Asian patients who underwent primary THA without pharmacologic prophylaxis.

METHODS

We retrospectively evaluated all 861 patients who underwent 992 elective primary THAs from May 2003 to December 2009. We identified patients with symptomatic DVT, symptomatic PE, and fatal PE. For potential risk factors we considered age, gender, body mass index (BMI), administration of aspirin, type of anesthesia, operation time, approach, simultaneous bilateral THAs, and duration of immobilization between symptomatic and asymptomatic patients.

RESULTS

We identified eight patients with symptomatic DVT, one of whom also had a symptomatic PE; there were no cases of fatal PE. The incidences of fatal PE, symptomatic PE, and symptomatic DVT were 0 %, 0.1 %, and 0.8 %, respectively. Longer duration of immobilization predicted symptomatic DVT or PE.

CONCLUSIONS

East Asian patients have a low incidence of symptomatic DVT and PE and virtually no fatal PEs after primary THA. The incidences and risk factors should be taken into consideration when deciding whether to prophylactically treat these patients with pharmacologic agents.

LEVEL OF EVIDENCE

Level IV, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.

摘要

背景

在西方国家,全髋关节置换术后(THA)后深静脉血栓形成(DVT)和肺栓塞(PE)较为常见,许多外科医生建议常规应用药物预防血栓形成。文献中有些提示表明东亚患者的 DVT 和 PE 发生率可能较低。因此,在未接受药物预防的大量东亚患者中确定这些发生率非常重要。

目的

因此,我们在未接受药物预防的一系列东亚原发性 THA 患者中,确定了 DVT 和 PE 的发生率,并评估了相关的危险因素。

方法

我们回顾性评估了 2003 年 5 月至 2009 年 12 月期间进行的 992 例择期原发性 THA 的 861 例患者。我们确定了有症状性 DVT、有症状性 PE 和致命性 PE 的患者。对于潜在的危险因素,我们考虑了年龄、性别、体重指数(BMI)、阿司匹林的应用、麻醉类型、手术时间、手术入路、同期双侧 THA 以及有症状和无症状患者之间的固定时间。

结果

我们确定了 8 例有症状性 DVT 的患者,其中 1 例还患有有症状性 PE;无致命性 PE 病例。致命性 PE、有症状性 PE 和有症状性 DVT 的发生率分别为 0%、0.1%和 0.8%。较长的固定时间可预测有症状性 DVT 或 PE。

结论

东亚患者在初次 THA 后发生有症状性 DVT 和 PE 的发生率较低,几乎没有致命性 PE。在决定是否预防性使用药物预防这些患者发生血栓形成时,应考虑这些发生率和危险因素。

证据水平

IV 级,预后研究。完整的证据水平描述请参见作者指南。

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