二羟基富马酸在水中的非对映选择性自缩合：潜在的糖合成途径。
Diastereoselective self-condensation of dihydroxyfumaric acid in water: potential route to sugars.
机构信息
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8127-30. doi: 10.1002/anie.201102045. Epub 2011 Jul 11.
PMID:21748829
Abstract
Jack of all trades: water-soluble salts of DHF underwent self-condensation to afford the threo diastereomer of pentulosonic acid, through differing reaction pathways contingent on the metal salt used. This transformation exemplifies the diverging roles of DHF as a nucleophile (a synthon for α-hydroxyacetyl anion) and an electrophile (an α-carboxyglycolaldehyde equivalent).
摘要
万金油
DHF 的水溶性盐通过不同的反应途径进行自身缩合，得到戊糖二酸的 threo 非对映异构体，这取决于所使用的金属盐。这种转化体现了 DHF 作为亲核试剂（α-羟乙酰阴离子的前体）和亲电试剂（α-羰代乙二醇醛等价物）的不同作用。
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