Bak Marek, Czerniak Maciej, Kicińska-Krogulska Magda, Michowicz Aleksandra, Krakowiak Anna
Oddział Toksykologii, Klinika Chorób Zawodowych i Toksykologii, Instytut Medycyny Pracy im. prof. J. Nofera, Łódź.
Med Pr. 2011;62(1):47-55.
Toxic liver injury poses an important heath problem in occupational medicine. Toxic response of this organ may arise from acute or chronic exposure to different substances. The final toxicological response to different toxicants may be defined as the regeneration of cells, loss of their function or necrosis. The morphology of toxic drug- or chemical-induced liver injury usuall differentiates into one of the following phenotypes: cholestatic injury, hepato- cellular injury, often associated with elevated l enzymes, mitochondrial injuries and delayed immunological injury. In this article, the authors present current knowledge of the pathogenesis of morphological changes in hepatocytes as the result of exposure to xenobiotics.
中毒性肝损伤是职业医学中一个重要的健康问题。该器官的毒性反应可能源于急性或慢性接触不同物质。对不同毒物的最终毒理学反应可定义为细胞再生、功能丧失或坏死。中毒性药物或化学物质所致肝损伤的形态学通常可分为以下几种表型之一：胆汁淤积性损伤、肝细胞损伤（常伴有肝酶升高）、线粒体损伤和迟发性免疫损伤。在本文中，作者介绍了接触外源性物质导致肝细胞形态学变化的发病机制的当前知识。
