Departamento de Producción Animal, ETS Ingenieros Agrónomos, UPM, Ciudad Universitaria s/n, Madrid, Spain.
J Anim Breed Genet. 2011 Aug;128(4):276-83. doi: 10.1111/j.1439-0388.2011.00933.x. Epub 2011 May 25.
An experiment with mice was designed to test the relative efficiency of three selection methods that help to minimize the rate of inbreeding during selection. A common house mice (Mus musculus) population was selected for 17 generations to increase the weight gain between 21 and 42 days. The population was split at random into three lines A, B and C where three selection methods were applied: individual selection and random mating, weighted selection with random mating and individual selection with minimum coancestry mating, respectively. There were three replicates for each line. Cumulated selection response was similar in the three lines, but there were differences in the level of inbreeding attained (in percentage): 31.24 (method A), 24.72 (method B) and 27.88 (method C). As consequence, lines B and C (weighted selection and minimum coancestry) showed a lower value of deterioration of fitness traits (the intrauterine mortality and the mortality at birth) than line A (random mating).
设计了一项针对小鼠的实验，以测试三种选择方法的相对效率，这些方法有助于在选择过程中最小化近交率。对一个常见的家鼠（Mus musculus）种群进行了 17 代选择，以增加 21 至 42 天之间的体重增加。该种群随机分为三个品系 A、B 和 C，分别应用三种选择方法：个体选择和随机交配、加权选择和随机交配以及个体选择和最小亲缘交配。每个品系有三个重复。三种方法的累积选择反应相似，但达到的近交程度（百分比）不同：31.24%（方法 A）、24.72%（方法 B）和 27.88%（方法 C）。因此，品系 B 和 C（加权选择和最小亲缘交配）的适应度特征（子宫内死亡率和出生时死亡率）下降值低于品系 A（随机交配）。
