Division of Key Lab of Animal Disease Diagnosis and Immunology of China's Department of Agriculture, College of Veterinary Medicine, Nanjing Agriculture University, Nanjing, 210095, People's Republic of China.
Amino Acids. 2012 Jun;42(6):2215-22. doi: 10.1007/s00726-011-0961-8. Epub 2011 Jul 13.
The bursa of Fabricius (BF) is the central humoral immune organ unique to birds. Here, we isolated a novel bursal pentapeptide I (BPP-I), LGPGP, from BF. BPP-I could play inhibition effect on MCF-7 but not on CEF or Vero cell proliferation in vitro, and enhance antitumor factor p53 protein expression. Also, BPP-I stimulated antibody production in a dose-dependent manner in hybridoma cell. Furthermore, BPP-I could induce various immune responses in mice immunization experiments, including increase antibody production and cytokines IL-4 and IFN-γ level, and induce T-cell immunophenotyping. These results suggest that BPP-I is a potential immunomodulator of antitumor and immunity. The study could provide some novel insights on the probable candidate reagent for the antitumor and immune improvement.
法氏囊（BF）是鸟类特有的中央体液免疫器官。在这里，我们从 BF 中分离出一种新型的囊五肽 I（BPP-I），LGPGP。BPP-I 可在体外抑制 MCF-7 但不抑制 CEF 或 Vero 细胞的增殖，并增强抑癌因子 p53 蛋白的表达。此外，BPP-I 可刺激杂交瘤细胞以剂量依赖性方式产生抗体。此外，BPP-I 可在小鼠免疫实验中诱导各种免疫反应，包括增加抗体产生和细胞因子 IL-4 和 IFN-γ水平，并诱导 T 细胞免疫表型。这些结果表明，BPP-I 是一种具有抗肿瘤和免疫调节潜力的免疫调节剂。该研究可为抗肿瘤和免疫改善的候选试剂提供一些新的见解。
