他汀类药物的使用与 2 项美国前瞻性队列研究中的肾细胞癌风险。
Statin use and the risk of renal cell carcinoma in 2 prospective US cohorts.
机构信息
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Cancer. 2012 Feb 1;118(3):797-803. doi: 10.1002/cncr.26338. Epub 2011 Jul 12.
BACKGROUND
Statins are widely used cholesterol-lowering agents that may have potential antitumor effect. Epidemiological studies on statin use and renal cell carcinoma (RCC) risk have been inconsistent.
METHODS
The authors investigated the association between statin use and RCC risk in the Nurses' Health Study and Health Professionals Follow-Up Study. In total, 80,782 women and 37,869 men were followed for 14 years and 16 years, respectively. Regular statin use was assessed at baseline and was updated biennially during follow-up. RCC diagnosis was confirmed by medical record review.
RESULTS
Two hundred seventy-seven incident RCC cases (164 women and 113 men) were identified. Compared with no current use, the multivariate relative risks of current statin use were 0.68 (95% confidence interval, 0.46-1.00) in women and 1.17 (95% confidence interval, 0.75-1.82) in men. The results for ever versus never users of statins were similar. No dose-response relation with duration of statin use and RCC risk was observed. On subgroup analyses, statin use was associated with a reduced RCC risk among women who had no history of hypertension.
CONCLUSIONS
The current study indicated that statin use may be associated with a lower risk of RCC in women, although these results need to be investigated further.
背景
他汀类药物是广泛使用的降胆固醇药物，可能具有潜在的抗肿瘤作用。关于他汀类药物使用与肾细胞癌（RCC）风险的流行病学研究结果并不一致。
方法
作者在护士健康研究和健康专业人员随访研究中调查了他汀类药物使用与 RCC 风险之间的关联。共有 80782 名女性和 37869 名男性分别随访了 14 年和 16 年。在基线时评估了他汀类药物的常规使用情况，并在随访期间每两年更新一次。通过病历审查确认 RCC 诊断。
结果
共确定了 277 例 RCC 病例（164 名女性和 113 名男性）。与未使用相比，女性当前使用他汀类药物的多变量相对风险为 0.68（95%置信区间，0.46-1.00），男性为 1.17（95%置信区间，0.75-1.82）。曾经使用与从未使用他汀类药物的结果相似。未观察到他汀类药物使用持续时间与 RCC 风险之间的剂量-反应关系。在亚组分析中，在没有高血压病史的女性中，他汀类药物的使用与 RCC 风险降低相关。
结论
目前的研究表明，他汀类药物的使用可能与女性 RCC 风险降低有关，但这些结果需要进一步研究。
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