Xiang Yu-Tao, Wang Chuan-Yue, Si Tian-Mei, Lee Edwin H M, He Yan-Ling, Ungvari Gabor S, Chiu Helen F K, Yang Shu-Yu, Chong Mian-Yoon, Tan Chay-Hoon, Kua Ee-Heok, Fujii Senta, Sim Kang, Yong Michael K H, Trivedi Jitendra K, Chung Eun-Kee, Udomratn Pichet, Chee Kok-Yoon, Sartorius Norman, Shinfuku Naotaka
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, China.
Hum Psychopharmacol. 2011 Jun-Jul;26(4-5):352-7. doi: 10.1002/hup.1213. Epub 2011 Jul 12.
The purpose of the study was to evaluate the frequency of reported sexual dysfunction (SD) in schizophrenia and its associations with sociodemographic and clinical variables in selected Asian countries.
A total of 5877 schizophrenia patients in nine Asian countries and territories were examined between 2001 and 2009. The patients' sociodemographic and clinical characteristics, prescription of psychotropic drugs, and drug-induced side effects were recorded using a standardized protocol and data collection. SD was evaluated as "present" or "absent" according to the clinical judgment of experienced psychiatrists.
The frequency of reported SD in the whole sample in women and men was 3.0%, 0.8%, and 4.6%, respectively, with variations across study sites. In the multivariate analyses, male sex, more second-generation antipsychotics, benzodiazepines, and antidepressants were independently associated with higher likelihood of reported SD, whereas negative symptoms had an inverse association with reported SD.
The results of this study indicate that SD was seldom recorded as a side effect by Asian psychiatrists while treating patients with schizophrenia. It is unclear whether the low prevalence of reported SD compared with Western data is real or whether the results are being insufficiently recognized.
本研究旨在评估亚洲部分国家精神分裂症患者中报告的性功能障碍（SD）的发生率及其与社会人口统计学和临床变量的关联。
2001年至2009年期间，对9个亚洲国家和地区的5877例精神分裂症患者进行了检查。使用标准化方案和数据收集记录患者的社会人口统计学和临床特征、精神药物处方以及药物引起的副作用。根据经验丰富的精神科医生的临床判断，将SD评估为“存在”或“不存在”。
在整个样本中，女性和男性报告的SD发生率分别为3.0%、0.8%和4.6%，各研究地点存在差异。在多变量分析中，男性、更多使用第二代抗精神病药物、苯二氮䓬类药物和抗抑郁药与报告SD的可能性较高独立相关，而阴性症状与报告的SD呈负相关。
本研究结果表明，亚洲精神科医生在治疗精神分裂症患者时很少将SD记录为副作用。与西方数据相比，报告的SD低患病率是真实情况还是未得到充分认识，目前尚不清楚。
