Marigot Ltd, Strand Farm, Currabinny, Carrigaline, Co. Cork, Ireland.
Phytother Res. 2012 Mar;26(3):375-80. doi: 10.1002/ptr.3561. Epub 2011 Jul 12.
Osteoporosis is a global health problem characterized by low bone mass and an increase in bone fragility. It is now well accepted that dietary factors play a central role in bone development and health. Diet that lacks adequate minerals is considered to be a risk factor for osteoporosis. The food supplement, Aquamin, is a natural, multi-mineral derived from the red algae Lithothamnion corallioides, rich in calcium, magnesium and 72 other trace minerals. The aim of this study was to evaluate the effect of Aquamin on osteoblastic behaviour and mineralisation in a pre-osteoblastic cell line. Cell number and metabolic activity were assessed using Hoescht DNA and AlamarBlue assays respectively. Osteogenic differentiation was measured using an alkaline phosphatase assay while mineralisation was determined using von Kossa and alizarin red staining. It is reported here that Aquamin promotes increased mineralisation in osteoblast cell culture. These data suggest that the nutritional supplement Aquamin plays an important role in promoting bone formation and may be useful in treating bone diseases such as osteoporosis.
骨质疏松症是一种全球性的健康问题，其特征是骨量低和骨脆性增加。现在人们普遍认为，饮食因素在骨骼发育和健康中起着核心作用。缺乏足够矿物质的饮食被认为是骨质疏松症的一个危险因素。食品补充剂 Aquamin 是一种天然的、多矿物质的物质，来源于红藻 Lithothamnion corallioides，富含钙、镁和 72 种其他微量元素。本研究的目的是评估 Aquamin 对成骨细胞前体细胞系中成骨细胞行为和矿化的影响。使用 Hoechst DNA 和 AlamarBlue 测定法分别评估细胞数量和代谢活性。碱性磷酸酶测定法用于测量成骨分化，茜素红和 von Kossa 染色用于测定矿化。本文报道 Aquamin 可促进成骨细胞培养中的矿化增加。这些数据表明，营养补充剂 Aquamin 在促进骨形成方面发挥着重要作用，可用于治疗骨质疏松症等骨骼疾病。
