Shelat V G, Seah M, Lim K H
Division of Upper Gastrointestinal Surgery, Department of Surgery, Tan Tock Seng Hospital, Singapore.
J Assoc Physicians India. 2011 Jan;59:57-9.
Drug induced oesophageal disease is common. Doxycycline is one of the commonest cause of drug induced oesophageal ulcers. The medical community often under recognizes the importance of drug induced oesophageal lesions and fails to deliver proper advice and instructions related to drug ingestion. The diagnosis is usually clinical although endoscopy is the gold standard diagnostic tool. Treatment is symptomatic with discontinuation of the drug often being sufficient. Long-term sequelae are infrequent and acute complications uncommon.
A 22-year-old college student was prescribed doxycycline capsules for acne and developed dysphagia. Upper gastrointestinal endoscopy revealed acute erosive oesophagitis.
She was managed symptomatically with proton pump inhibitors and her dysphagia improved over a period of three days. She was discharged with proper advice regarding medication ingestion and proton pump inhibitor for four weeks.
Drug induced oesophageal disease is a preventable self-limiting condition. Proper advice regarding medication ingestion is essential for prevention.
药物性食管疾病很常见。多西环素是药物性食管溃疡最常见的病因之一。医学界常常未充分认识到药物性食管病变的重要性，也未能提供与药物服用相关的恰当建议和指导。诊断通常依靠临床症状，尽管内镜检查是金标准诊断工具。治疗以对症治疗为主，通常停用药物就足够了。长期后遗症不常见，急性并发症也不多见。
一名22岁的大学生因痤疮被开了多西环素胶囊，随后出现吞咽困难。上消化道内镜检查显示为急性糜烂性食管炎。
她接受了质子泵抑制剂的对症治疗，吞咽困难在三天内有所改善。她出院时得到了关于药物服用的恰当建议，并服用了四周的质子泵抑制剂。
药物性食管疾病是一种可预防的自限性疾病。关于药物服用的恰当建议对预防至关重要。
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