Kadayifci A, Gulsen M T, Koruk M, Savas M C
Department of Gastroenterology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
Dis Esophagus. 2004;17(2):168-71. doi: 10.1111/j.1442-2050.2004.00384.x.
Pill-induced esophagitis is a complication seen in patients who use certain medications such as tetracycline and non-steroidal anti-inflammatory drugs. In this short report, we described five cases of doxycycline-induced esophagitis with endoscopic images. All of the patients were young or middle-aged women. Dysphagia or odynophagia with retrosternal pain were the main presenting symptoms in all cases. The observed injuries were at the middle third of esophagus with a normal surrounding mucosa. All patients had a history of swallowing the capsule with a small amount of water or in a recumbent position. Two patients with dysphagia were managed by intravenous fluid support and parenteral acid suppression. The symptoms were improved in 2-7 days after the ceasing of the drug and control endoscopies were completely normal in all cases after 3-4 weeks of admission. The drug-induced esophagitis is not rare with certain drugs and should be suspected in all patients presenting with chest pain and dysphagia. Physicians must warn the patients to take the pills and capsules with enough liquid and in the upright position.
药物性食管炎是使用某些药物（如四环素和非甾体类抗炎药）的患者中出现的一种并发症。在本简短报告中，我们描述了5例伴有内镜图像的多西环素所致食管炎病例。所有患者均为中青年女性。吞咽困难或吞咽痛伴胸骨后疼痛是所有病例的主要症状。观察到的损伤位于食管中1/3处，周围黏膜正常。所有患者都有少量饮水或卧位吞咽胶囊的病史。2例吞咽困难患者接受了静脉补液支持和胃肠外抑酸治疗。停药后2 - 7天症状改善，入院3 - 4周后所有病例的对照内镜检查完全正常。药物性食管炎在使用某些药物时并不罕见，所有出现胸痛和吞咽困难的患者都应怀疑患有该病。医生必须告诫患者用足够的液体送服丸剂和胶囊，并保持直立姿势。
