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[结膜囊内 topical 散瞳与浸泡纤维素实现散瞳的比较] (注:这里“topical”可能有更准确的医学专业释义,需结合更完整语境判断,仅按字面翻译为“局部的、 topical” )

[Comparison of topic mydriasis and mydriasis achieved by soaked cellulose in the conjunctival sac].

作者信息

Trnavec B, Cernák A, Vodrázková E

机构信息

Ocná klinika IF SZU a UNB, Nemocnica sv Cyrila a Metoda, Bratislava, Slovensko.

出版信息

Cesk Slov Oftalmol. 2011 Apr;67(2):60-2.

Abstract

AIM

To compare mydriasis before the cataract surgery after the local application of mydriatics in to the conjunctival sac with mydriasis achieved using the mydriatic solution in soaked piece of cellulose applied in to the lower fornix. The same mydriatics (tropicamide 0.5 %, phenylephrine 10%, and homatropine 4 %) were used.

METHODS

In a prospective, non-randomized study the authors measured maximal artificial mydriasis in 100 patients (60 women, 40 men) in 100 eyes before the cataract surgery. The mean age of the patients was 70.17 years (range, 42 - 91 years). The patients were divided into two groups (A, B), each of 50 persons: In the group A, during the 10 - 15 minutes period, the mydriatics, tropicamide 0.5%, phenylephrine 10%, and homatropine 4%, were topically applied three times. In the patients of the B group, the conjunctival sac was anesthetized by oxybuprocaine 0.4%; and afterwards, a cut piece of cellulose (Kettenbach) soaked in to the mydriatics solution was applied for 30 - 40 minutes in to the conjunctival sac and the eyelids were taped together. The mydriatic solution was mixed by tropicamide 0.5%, phenylephrine 10%, and homatropine 4%, of equal doses. On the surgery table, before the operation, th soaked cellulose was removed, and thereafter the achieved preoperative horizontal size of the pupil was measured with caliper under the operation microscope. The achieved preoperative pupillary width in the group A and B were compared. The authors noticed also subjective symptoms and objective signs in both groups of patients. For statistical comparison of the average mydriasis between the A and B group of patients, the unpaired Student t test was used. As statistically significant we considered p < 0.05.

RESULTS

The average mydriasis in the A group (mydriatic drops topically) was 7.84 +/- 0.99 mm. In the B group of patients (cut piece of cellulose soaked in to the mydriatics solution), the average mydriasis was 7.94 +/- 1.03 mm. The authors did not found significant difference in the diameters between the A and the B group of patients (p = 0.622; p > 0.05). In the B group of patients, subjective symptoms as well as objective signs appeared (burning sensation, sticking, pain, and corneal epithelium erosion); these problems were caused by the triangle shape and the size of the cut cellulose piece.

CONCLUSION

Artificial preoperative mydriasis in patients in both our groups was very good. Topic classically introduced preoperative mydriasis has its stable place also in contemporary modern cataract surgery; the mydriasis achieved by soaked cellulose may save the nurses' time.

摘要

目的

比较在结膜囊局部应用散瞳剂后白内障手术前的散瞳效果与将散瞳剂溶液浸泡在纤维素片中置于下穹窿所达到的散瞳效果。使用相同的散瞳剂(0.5%托吡卡胺、10%去氧肾上腺素和4%后马托品)。

方法

在一项前瞻性、非随机研究中,作者测量了100例患者(60名女性,40名男性)100只眼睛在白内障手术前的最大人工散瞳情况。患者的平均年龄为70.17岁(范围42 - 91岁)。患者被分为两组(A组、B组),每组50人:A组在10 - 15分钟内,将0.5%托吡卡胺、10%去氧肾上腺素和4%后马托品这三种散瞳剂局部应用三次。B组患者用0.4%奥布卡因对结膜囊进行麻醉;之后,将浸泡在散瞳剂溶液中的一片纤维素(凯腾巴赫公司生产)置于结膜囊内30 - 40分钟,并将眼睑粘在一起。散瞳剂溶液由等量的0.5%托吡卡胺、10%去氧肾上腺素和4%后马托品混合而成。在手术台上,手术前,取出浸泡的纤维素,然后在手术显微镜下用卡尺测量术前达到的瞳孔水平大小。比较A组和B组术前达到的瞳孔宽度。作者还观察了两组患者的主观症状和客观体征。为了对A组和B组患者的平均散瞳情况进行统计学比较,使用了非配对学生t检验。我们认为p < 0.05具有统计学意义。

结果

A组(局部应用散瞳滴眼液)的平均散瞳值为7.84 +/- 0.99毫米。B组患者(浸泡在散瞳剂溶液中的纤维素片)的平均散瞳值为7.94 +/- 1.03毫米。作者未发现A组和B组患者瞳孔直径有显著差异(p = 0.622;p > 0.05)。在B组患者中出现了主观症状和客观体征(烧灼感、粘连、疼痛和角膜上皮糜烂);这些问题是由纤维素片的三角形形状和大小引起的。

结论

我们两组患者术前的人工散瞳效果都非常好。传统的术前散瞳方法在当代现代白内障手术中也有其稳固的地位;浸泡纤维素片达到的散瞳效果可能节省护士的时间。

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