Wang Ya-Ping, Shao Jie, Zhuang Xue-Ling
Department of Child Health Care, Children's Hospital Affiliated to Zhejiang University, Hangzhou 310003, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2011 Jul;13(7):535-8.
To study the prevalence of iron deficiency in children between 6 months and 7 years and to study the diagnostic value of soluble transferrin receptor (sTfR) for iron deficiency in the children.
A total of 502 healthy children between 6 months and 7 years from Hangzhou City of Zhejiang Province were enrolled. Serum sTfR, serum ferritin (SF), serum iron (SI), total iron blinding capacity (TIBC), zinc protoporphyrin (ZPP), Hb, MCV and CRP levels were measured.
The prevalence rate of iron deficiency was 19.5% in children at ages of 6 months to 7 years. The prevalence rate of iron deficiency was the highest in infants (≤1 year old; 34.7%), followed by in toddlers (1-3 years old; 19.4%) and preschoolers (3-7 years old; 14.0%). The mean serum sTfR level in infants (2.02±0.73 mg/L) was significantly higher than that in toddlers (1.68±0.40 mg/L) and preschoolers (1.67±0.29 mg/L) (P<0.05).The best cut-off value of serum sTfR for the diagnosis of iron deficiency was 2.02 mg/L in infants (sensitivity: 70.3%, specificity: 82.2%). The best cut-off value was 1.85 mg/L in toddlers (sensitivity: 71.7%; specificity: 86.4%), and that was 1.85 mg/L in preschoolers (sensitivity: 77.8%; specificity: 88.6%). Serum sTfR was correlated with SF (r=0.107, P<0.05), TIBC (r=0.276, P<0.01), TS (r=-0.139, P<0.05), ZPP (r=0.175, P<0.01) and MCV (r=-0.140, P<0.01).
Iron deficiency is more prevalent in infants ≤1 year old. The mean serum level and the cut-off value of sTfR in infants are higher than in toddlers and preschoolers. Serum sTfR is an effective index for the diagnosis of iron deficiency in children, especially in infants≤ 1 year old.
研究6个月至7岁儿童缺铁的患病率，并探讨可溶性转铁蛋白受体（sTfR）对儿童缺铁的诊断价值。
纳入浙江省杭州市502名6个月至7岁的健康儿童。检测血清sTfR、血清铁蛋白（SF）、血清铁（SI）、总铁结合力（TIBC）、锌原卟啉（ZPP）、血红蛋白（Hb）、平均红细胞体积（MCV）和C反应蛋白（CRP）水平。
6个月至7岁儿童缺铁患病率为19.5%。缺铁患病率在婴儿（≤1岁；34.7%）中最高，其次是幼儿（1 - 3岁；19.4%）和学龄前儿童（3 - 7岁；14.0%）。婴儿的血清sTfR平均水平（2.02±0.73 mg/L）显著高于幼儿（1.68±0.40 mg/L）和学龄前儿童（1.67±0.29 mg/L）（P<0.05）。婴儿诊断缺铁时血清sTfR的最佳截断值为2.02 mg/L（敏感性：70.3%，特异性：82.2%）。幼儿的最佳截断值为1.85 mg/L（敏感性：71.7%；特异性：86.4%），学龄前儿童的最佳截断值为1.85 mg/L（敏感性：77.8%；特异性：88.6%）。血清sTfR与SF（r = 0.107，P<0.05）、TIBC（r = 0.276，P<0.01）、转铁蛋白饱和度（TS）（r = -0.139，P<0.05）、ZPP（r = 0.175，P<0.01）和MCV（r = -0.140，P<0.01）相关。
≤1岁婴儿缺铁更为普遍。婴儿血清sTfR的平均水平和截断值高于幼儿和学龄前儿童。血清sTfR是诊断儿童缺铁，尤其是≤1岁婴儿缺铁的有效指标。
