Niu Zhi-Min, Li Yan-Hong, Jiang Shun-Jie, Mao Xiang-Ying, Li Yu-Jie
Department of Pediatrics, Changyuan People's Hospital, Changyuan, Henan 453400, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2011 Jul;13(7):543-6.
To study the prognosis and the factors affecting the prognosis in children with acute respiratory distress syndrome (ARDS).
Seventy-eight children with ARDS were enrolled. The states of their survival within 30 days were followed-up.
Of the 78 children with ARDS, 51 cases demised, 27 cases survived, with a 30-days survival rate of 35%. The average survival time was 14.4 days (median: 8 days). The peak of death appeared within 3 days after ARDS. There were significant differences in aspects of age, primary disease, percentage of neonatal hyaline membrane disease, pediatric critical illness score (PCIS), duration of mechanical ventilation, oxygenation index (PaO(2)/FiO(2)), white blood cell count and number of involved organs between the died and survived children (P<0.05 or 0.01). The Cox multiple factors analysis showed that the age (HR 3.924~3.938), primary disease (HR=1.817) and PCIS (HR=0.469) were the risk factors of death.
The peak of death usually appears within 3 days after ARDS. Age, primary disease and PCIS are the independent factors of prognosis in children with ARDS.
研究儿童急性呼吸窘迫综合征（ARDS）的预后及影响预后的因素。
纳入78例ARDS患儿，随访其30天内的生存情况。
78例ARDS患儿中，死亡51例，存活27例，30天生存率为35%。平均生存时间为14.4天（中位数：8天）。死亡高峰出现在ARDS发生后3天内。死亡患儿与存活患儿在年龄、原发病、新生儿肺透明膜病所占比例、小儿危重病评分（PCIS）、机械通气时间、氧合指数（PaO₂/FiO₂）、白细胞计数及受累器官数目等方面差异有统计学意义（P<0.05或0.01）。Cox多因素分析显示年龄（HR 3.924～3.938）、原发病（HR=1.817）及PCIS（HR=0.469）是死亡的危险因素。
死亡高峰通常出现在ARDS发生后3天内。年龄、原发病及PCIS是儿童ARDS预后的独立影响因素。
