Ma Xiu-Li, Zhen Yan-Fen
Department of Pediatrics, 253rd Hospital of People's Liberation Army, Huhhot, Inner Mongolia 010051, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2011 Jul;13(7):551-3.
To study the changes and clinical significance of serum levels of 25-(OH)D(3) and total IgE in children with asthma.
Thirty children with asthma, 40 children with asthmatic bronchitis, and 40 healthy children were enrolled. Double-antibody radioimmunoassay was used to detect the levels of serum 25-(OH)D(3) and total IgE.
Serum 25-(OH)D(3) levels (18±3 ng/Ml)decreased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (43±3 ng/mL) and the control group (43±3 ng/mL) (P<0.01). In contrast, serum total IgE levels (192±16 IU/mL) increased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (123±14 IU/mL) and the control group (118±15 IU/mL) (P<0.01). Serum 25-(OH)D(3) levels were negatively correlated with serum total IgE levels in asthmatic children (r=-0.783, P<0.01). There were no correlation between serum 25-(OH)D(3) levels and serum total IgE level in the asthmatic bronchitis and the control groups.
25-(OH)D(3) may play an important role in the pathogenesis of asthma. The increased serum 25-(OH)D(3) level may inhibit total IgE expression, suggesting that increasing serum 25-(OH)D(3) level might be a new option for the prevention and treatment of asthma.
研究哮喘患儿血清25 -（OH）D（3）和总IgE水平的变化及其临床意义。
选取30例哮喘患儿、40例喘息性支气管炎患儿和40例健康儿童。采用双抗体放射免疫法检测血清25 -（OH）D（3）和总IgE水平。
哮喘组血清25 -（OH）D（3）水平（18±3 ng/Ml）较喘息性支气管炎组（43±3 ng/mL）和对照组（43±3 ng/mL）显著降低（P<0.01）。相反，哮喘组血清总IgE水平（192±16 IU/mL）较喘息性支气管炎组（123±14 IU/mL）和对照组（118±15 IU/mL）显著升高（P<0.01）。哮喘患儿血清25 -（OH）D（3）水平与血清总IgE水平呈负相关（r=-0.783，P<0.01）。喘息性支气管炎组和对照组血清25 -（OH）D（3）水平与血清总IgE水平无相关性。
25 -（OH）D（3）可能在哮喘发病机制中起重要作用。血清25 -（OH）D（3）水平升高可能抑制总IgE表达，提示提高血清25 -（OH）D（3）水平可能是预防和治疗哮喘的新选择。
