Institute for Biomedicine, Aarhus University, Aarhus, Denmark.
Neurobiol Aging. 2011 Nov;32(11):1927-31. doi: 10.1016/j.neurobiolaging.2011.05.006. Epub 2011 Jul 14.
Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex.
现代体视学技术已被用于显示，在 18 个月大的 APPswe/PS1deltaE9 小鼠大脑皮层中，胆碱能纤维的总长度减少了近 300 米，并且与转基因诱导的淀粉样变性的量呈非线性关系。这些数据提供了严格的定量形态学证据，表明类似阿尔茨海默病的淀粉样变性会影响大脑皮层胆碱能神经支配的轴突。
