[痛风的流行病学与遗传学]

[The epidemiology and genetic of gout].

作者信息

Bardin Thomas, Richette Pascal

机构信息

Université Paris 7, Assistance-publique-Hôpitaux de Paris, hôpital Lariboisière, UFR médicale, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.

出版信息

Presse Med. 2011 Sep;40(9 Pt 1):830-5. doi: 10.1016/j.lpm.2011.04.012. Epub 2011 Jul 12.

DOI:10.1016/j.lpm.2011.04.012

PMID:21752574

Abstract

Gout affects 1-2% of adults in developed countries, where it is the most common inflammatory arthritis in men. Epidemiological data are consistent with a rise in the prevalence of gout. Diet and genetic predisposition seem to be the main causal factors of primary gout. Gout and hyperuricaemia are associated with hypertension, diabetes mellitus, metabolic syndrome, and renal and cardiovascular diseases. Genetic studies have found that variants of GLUT9 and ABCG2 were associated with urate levels.

摘要

在发达国家，痛风影响1%至2%的成年人，是男性中最常见的炎性关节炎。流行病学数据显示痛风患病率呈上升趋势。饮食和遗传易感性似乎是原发性痛风的主要致病因素。痛风和高尿酸血症与高血压、糖尿病、代谢综合征以及肾脏和心血管疾病相关。基因研究发现，葡萄糖转运蛋白9（GLUT9）和三磷酸腺苷结合盒转运体G2（ABCG2）的变异与尿酸水平有关。