Memorial Sloan-Kettering Cancer Center, NY 10065, USA.
Best Pract Res Clin Obstet Gynaecol. 2011 Dec;25(6):773-82. doi: 10.1016/j.bpobgyn.2011.06.003. Epub 2011 Jul 14.
Uterine sarcomas are rare, high-risk malignancies. Expert histologic review is important for accurate diagnosis. For high-grade leiomyosarcomas, the risk of recurrence is high after complete resection of uterus-limited disease; however, no adjuvant therapy has been proven to improve survival. Chemotherapy regimens with efficacy in treating advanced uterine leiomyosarcoma include gemcitabine-docetaxel, doxorubicin and ifosfamide. Uterine carcinosarcomas also carry a high risk of recurrence. Adjuvant chemotherapy is a standard approach for completely resected and metastatic carcinosarcoma. Active agents include carboplatin, cisplatin, ifosfamide and paclitaxel.
子宫肉瘤是罕见的、高风险的恶性肿瘤。专家进行组织学审查对于准确诊断很重要。对于高级别平滑肌肉瘤，在子宫局限性疾病完全切除后复发风险较高；然而，尚无辅助治疗被证明可以提高生存率。在治疗晚期子宫平滑肌肉瘤方面有效的化疗方案包括吉西他滨-多西他赛、多柔比星和异环磷酰胺。子宫癌肉瘤也有很高的复发风险。对于完全切除和转移性癌肉瘤，辅助化疗是一种标准方法。有效的药物包括卡铂、顺铂、异环磷酰胺和紫杉醇。
