Woods S W, Charney D S, Delgado P L, Heninger G R
Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven 06508.
J Clin Psychiatry. 1990 Dec;51(12):505-7.
The authors examined whether long-term treatment with imipramine would decrease CO2-induced anxiety in 10 patients with panic disorder. The patients underwent CO2 testing after single-blind placebo testing and again after imipramine treatment. Scores on self-rated visual analog mood scales and panic attack symptom scales showed that the anxiogenic effects of CO2 were significantly reduced during long-term imipramine treatment. These results suggest that the mechanisms underlying CO2-induced anxiety may be similar to those involved in the pathophysiology of panic disorder.
作者研究了丙咪嗪长期治疗是否会减轻10例惊恐障碍患者由二氧化碳诱发的焦虑。患者在单盲安慰剂测试后以及丙咪嗪治疗后均接受了二氧化碳测试。自评视觉模拟情绪量表和惊恐发作症状量表的评分显示，在丙咪嗪长期治疗期间，二氧化碳的致焦虑作用显著降低。这些结果表明，二氧化碳诱发焦虑的潜在机制可能与惊恐障碍病理生理学中涉及的机制相似。
