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The role of NMDA receptors in epilepsy: II. Effects of NMDA receptor antagonists (CPP and MK-801) on hippocampal long-term potentiation in anesthetized rats.

作者信息

Morimoto K, Katayama K, Sato K, Ohnishi M, Okamoto M, Otsuki S

机构信息

Department of Neuropsychiatry, Okayama University Medical School.

出版信息

Jpn J Psychiatry Neurol. 1990 Jun;44(2):453-4.

PMID:2175367
Abstract
摘要

相似文献

1
The role of NMDA receptors in epilepsy: II. Effects of NMDA receptor antagonists (CPP and MK-801) on hippocampal long-term potentiation in anesthetized rats.
Jpn J Psychiatry Neurol. 1990 Jun;44(2):453-4.
2
The role of NMDA receptors in epilepsy: I. Effects of NMDA receptor antagonists (CPP and MK-801) on amygdala kindling in rats.N-甲基-D-天冬氨酸受体在癫痫中的作用：I. N-甲基-D-天冬氨酸受体拮抗剂（CPP和MK-801）对大鼠杏仁核点燃的影响
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N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus.CA1区中N-甲基-D-天冬氨酸受体依赖性长时程增强作用影响整个海马体中谷氨酸受体亚基及相关蛋白的突触表达。
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Epileptogenic insult causes a shift in the form of long-term potentiation expression.致痫性损伤导致长时程增强表达形式的转变。
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Long-term potentiation in the avian hippocampus does not require activation of the N-methyl-D-aspartate (NMDA) receptor.禽类海马体中的长时程增强并不需要N-甲基-D-天冬氨酸（NMDA）受体的激活。
Synapse. 1993 Feb;13(2):173-8. doi: 10.1002/syn.890130208.
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Antiepileptic effects of MK-801, a noncompetitive NMDA-receptor antagonist, in the low-frequency kindling model of epilepsy.
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L-687,414, a low efficacy NMDA receptor glycine site partial agonist in vitro, does not prevent hippocampal LTP in vivo at plasma levels known to be neuroprotective.L-687,414，一种在体外为低效N-甲基-D-天冬氨酸受体甘氨酸位点部分激动剂的物质，在已知具有神经保护作用的血浆水平下，不能在体内阻止海马体的长时程增强效应。
Br J Pharmacol. 1998 Aug;124(8):1767-73. doi: 10.1038/sj.bjp.0702010.
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Developmental lead (Pb) exposure reduces the ability of the NMDA antagonist MK-801 to suppress long-term potentiation (LTP) in the rat dentate gyrus, in vivo.发育期铅暴露会降低NMDA拮抗剂MK-801在体内抑制大鼠齿状回长时程增强（LTP）的能力。
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Dorsal hippocampus and classical fear conditioning to tone and context in rats: effects of local NMDA-receptor blockade and stimulation.大鼠背侧海马与对音调及环境的经典恐惧条件反射：局部NMDA受体阻断和刺激的影响
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N-methyl-D-aspartate receptor antagonists are less effective in blocking long-term potentiation at apical than basal dendrites in hippocampal CA1 of awake rats.在清醒大鼠海马CA1区，N-甲基-D-天冬氨酸受体拮抗剂在阻断顶端树突而非基底树突的长时程增强方面效果较差。
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引用本文的文献

1
Interplay of epilepsy and long-term potentiation: implications for memory.癫痫与长时程增强的相互作用：对记忆的影响
Front Neurosci. 2025 Jan 10;18:1451740. doi: 10.3389/fnins.2024.1451740. eCollection 2024.