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Hypoxia-induced expression of VEGF in the organotypic spinal cord slice culture.

作者信息

An Sung Su, Pennant William A, Ha Yoon, Oh Jin Soo, Kim Hyo Jin, Gwak So-Jung, Yoon Do Heum, Kim Keung Nyun

机构信息

Department of Neurosurgery, Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seodaemoon-gu, Seoul, Korea.

出版信息

Neuroreport. 2011 Jan 26;22(2):55-60. doi: 10.1097/WNR.0b013e3283418b00.

DOI:10.1097/WNR.0b013e3283418b00
PMID:21753742
Abstract

We used the erythropoietin enhancer and Simian virus-40 promoter to create a hypoxia-inducible gene expression system to investigate the effect of vascular endothelial growth factor (VEGF) gene therapy on neuroprotection and neurogenesis in organotypic spinal cord slice culture. The organotypic spinal cord slice culture transfected with pEpo-SV-VEGF expressed the highest amount of VEGF under hypoxic conditions and showed decreased apoptosis and increased proliferation, and evidence of neurogenesis. Our results show that the hypoxia-induced VEGF expression in an organotypic spinal cord slice culture may lead to an optimal treatment for spinal cord injury.

摘要

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