Zanwar Anand A, Hegde Mahabaleshwar V, Bodhankar Subhash L
Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Paud Road, Erandwane, Pune-411 038, Maharashtra, India.
Interdiscip Toxicol. 2011 Jun;4(2):90-7. doi: 10.2478/v10102-011-0016-8.
The objective of the study was to evaluate the cardioprotective activity of flax lignan concentrate (FLC) in isoprenalin (ISO) induced cardiotoxicity in rats. Male Wistar rats (200-230 g) were divided into three groups. Group I: control, Group II: isoprenalin, Group III: FLC (500 mg/kg, p.o.) orally for 8 days and in group II and III isoprenalin 5.25 mg/kg, s.c. on day 9 and 8.5 mg/kg on day 10. On day 10 estimation of marker enzymes in serum and haemodynamic parameters were recorded. Animals were sacrificed, histology of heart was performed. Isoprenalin showed cardiotoxicity, manifested by increased levels of marker enzymes and increased heart rate. FLC treatment reversed these biochemical changes significantly compared with ISO group. The cardiotoxic effect of isoprenalin was less in FLC pretreated animals, which was confirmed in histopathological alterations. Haemodynamic, biochemical alteration and histopathological results suggest a cardioprotective protective effect of FLC in isoprenalin induced cardiotoxicity.
本研究的目的是评估亚麻籽木脂素浓缩物（FLC）对异丙肾上腺素（ISO）诱导的大鼠心脏毒性的心脏保护活性。将雄性Wistar大鼠（200 - 230克）分为三组。第一组：对照组；第二组：异丙肾上腺素组；第三组：口服FLC（500毫克/千克，经口给药），持续8天，在第二组和第三组中，于第9天皮下注射5.25毫克/千克异丙肾上腺素，第10天皮下注射8.5毫克/千克异丙肾上腺素。在第10天记录血清中标记酶的含量及血流动力学参数。处死动物后，进行心脏组织学检查。异丙肾上腺素表现出心脏毒性，表现为标记酶水平升高和心率加快。与ISO组相比，FLC治疗显著逆转了这些生化变化。在经FLC预处理的动物中，异丙肾上腺素的心脏毒性作用较小，这在组织病理学改变中得到证实。血流动力学、生化改变和组织病理学结果表明，FLC对异丙肾上腺素诱导的心脏毒性具有心脏保护作用。
