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3-（4-氯-苯甲酰基）-4-（4-氯-苯基）-1-苯乙基-哌啶-4-醇

3-(4-Chloro-benzo-yl)-4-(4-chloro-phen-yl)-1-phenethyl-piperidin-4-ol.

作者信息

Aydın Abdullah, Akkurt Mehmet, Mete Ebru, Sahin Ertan, Gul Halise Inci

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1447-8. doi: 10.1107/S1600536811018034. Epub 2011 May 20.

DOI:10.1107/S1600536811018034
PMID:21754823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3120371/
Abstract

In the title compound, C(26)H(25)Cl(2)NO(2), the piperidine ring adopts a chair conformation with a cis configuration of the carbonyl and hy-droxy substituents. The dihedral angle between the aromatic rings of the chloro-benzene groups is 24.3 (2)°. The phenyl ring forms dihedral angles of 59.4 (3) and 44.1 (3)° with the benzene rings. In the crystal, mol-ecules are linked by inter-molecular O-H⋯N and C-H⋯O hydrogen bonds and C-H⋯π inter-actions into layers parallel to the bc plane.

摘要

在标题化合物C₂₆H₂₅Cl₂NO₂中，哌啶环呈椅式构象，羰基和羟基取代基为顺式构型。氯苯基团的芳环之间的二面角为24.3 (2)°。苯环与苯环形成的二面角分别为59.4 (3)°和44.1 (3)°。在晶体中，分子通过分子间的O-H⋯N和C-H⋯O氢键以及C-H⋯π相互作用连接成平行于bc平面的层。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46e/3120371/4f4256337b15/e-67-o1447-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46e/3120371/324d7e6e3880/e-67-o1447-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46e/3120371/1e504a74313f/e-67-o1447-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46e/3120371/4f4256337b15/e-67-o1447-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46e/3120371/324d7e6e3880/e-67-o1447-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46e/3120371/1e504a74313f/e-67-o1447-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46e/3120371/4f4256337b15/e-67-o1447-fig3.jpg

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