Jie Xiao, Rodriguez Blanca, Pueyo Esther
Oxford University, Oxford, UK.
Comput Cardiol (2010). 2010 Sep 26;2010:353-356.
Increased beat-to-beat variability of repolarization (BVR) has been suggested to indicate increased susceptibility to drug-induced arrhythmia. This study aimed to characterize BVR in patients before and after administration of sotalol, a torsadogenic antiarrhythmic drug, in the search for new biomarkers of proarrhythmic risk. ECG Recordings pre and post sotalol injection in two groups of patients (with and without history of drug-induced torsades de pointes) were obtained from THEW. ECG wave detection and delineation were performed via dyadic wavelet transform. BVR was evaluated by short-term variability (STV) of QTc interval and JT area. In both groups, sotalol resulted in significant increase in STV of JT area, while no significant change occurred in STV of QTc interval. Thus, STV of JT area, as a measure of BVR, has the potential to be a biomarker for drug toxicity.
复极化逐搏变异性（BVR）增加被认为表明对药物诱导的心律失常易感性增加。本研究旨在描述服用索他洛尔（一种致扭转型室性心动过速的抗心律失常药物）前后患者的BVR，以寻找促心律失常风险的新生物标志物。从THEW获取了两组患者（有和没有药物诱导的尖端扭转型室速病史）在注射索他洛尔前后的心电图记录。通过二进小波变换进行心电图波形检测和描绘。通过QTc间期和JT面积的短期变异性（STV）评估BVR。在两组中，索他洛尔均导致JT面积的STV显著增加，而QTc间期的STV无显著变化。因此，作为BVR测量指标的JT面积STV有可能成为药物毒性的生物标志物。
