Nai Gisele Alborghetti, Stuani Maria Luiza de Toledo, Stuani Luís Antonio Sasso
Department of Pathology, University of Western São Paulo, Presidente Prudente, SP, Brazil.
Rev Inst Med Trop Sao Paulo. 2011 May-Jun;53(3):165-8. doi: 10.1590/s0036-46652011000300008.
Mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. It is a localized chronic and deforming infectious disease of subcutaneous tissue, skin and bones. We report the first case of eumycetoma of the oral cavity in world literature.
A 43-year-old male patient, complaining of swelling and fistula in the hard palate. On examination, swelling of the anterior and middle hard palate, with fistula draining a dark liquid was observed. The panoramic radiograph showed extensive radiolucent area involving the region of teeth 21-26 and the computerized tomography showed communication with the nasal cavity, suggesting the diagnosis of periapical cyst. Surgery was performed to remove the lesion. Histopathological examination revealed purulent material with characteristic grain. Gram staining for bacteria was negative and Grocott-Gomori staining for the detection of fungi was positive, concluding the diagnosis of eumycetoma. The patient was treated with ketoconazole for nine months, and was considered cured at the end of treatment.
Histopathological examination, using histochemical staining, and direct microscopic grains examination can provide the distinction between eumycetoma and actinomycetoma accurately.
足菌肿是一种病理过程,其中来自外源的真菌性(真菌)或放线菌性病原体产生颗粒。它是一种皮下组织、皮肤和骨骼的局部慢性变形感染性疾病。我们报告了世界文献中首例口腔真菌性足菌肿病例。
一名43岁男性患者,主诉硬腭肿胀和瘘管形成。检查时,发现硬腭前部和中部肿胀,有瘘管排出深色液体。全景X线片显示21 - 26牙区域有广泛的透射区,计算机断层扫描显示与鼻腔相通,提示诊断为根尖囊肿。进行手术切除病变。组织病理学检查发现脓性物质中有特征性颗粒。细菌革兰氏染色阴性,检测真菌的Grocott - Gomori染色阳性,确诊为真菌性足菌肿。患者接受酮康唑治疗9个月,治疗结束时被认为已治愈。
使用组织化学染色的组织病理学检查和直接显微镜下颗粒检查可准确区分真菌性足菌肿和放线菌性足菌肿。