Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Virol. 2011 Oct;83(10):1733-7. doi: 10.1002/jmv.22153. Epub 2011 Jul 13.
Genetic factors of the host have been shown to influence the outcome of treatment for hepatitis C virus (HCV) infection. Killer cell immunoglobulin-like receptors (KIR) regulate natural killer (NK) cell activity by interaction with specific human leukocyte antigen (HLA) class I. In this study, KIR gene polymorphisms and their HLA ligands were investigated in 110 Thai patients with chronic HCV genotype 3a. Seventy-six patients were sustained virological responders and 34 patients were virological non-responders. KIR typing and HLA-C typing were performed using PCR-SSP (polymerase chain reaction with sequence specific primer). The frequency of HLA-C1C2 was significantly higher in sustained responders than in non-responders (P = 0.04). However, the frequencies of KIR2DL2/2DL3 genotype and KIR2DL2/2DL3-HLA-C1C1 genotype were significantly higher in non-responders than in sustained responders (P = 0.02, 0.004, respectively). In summary, this study showed the association of KIR genes and ligands with the outcome of antiviral treatment in chronic hepatic C virus genotype 3a infection.
宿主的遗传因素已被证明会影响丙型肝炎病毒 (HCV) 感染治疗的结果。杀伤细胞免疫球蛋白样受体 (KIR) 通过与特定的人类白细胞抗原 (HLA) Ⅰ类相互作用来调节自然杀伤 (NK) 细胞的活性。在这项研究中，研究了 110 例泰国慢性 HCV 基因型 3a 患者的 KIR 基因多态性及其 HLA 配体。76 例患者为持续病毒学应答者，34 例患者为病毒学无应答者。使用 PCR-SSP（聚合酶链反应与序列特异性引物）进行 KIR 分型和 HLA-C 分型。持续应答者中 HLA-C1C2 的频率明显高于无应答者（P=0.04）。然而，无应答者中 KIR2DL2/2DL3 基因型和 KIR2DL2/2DL3-HLA-C1C1 基因型的频率明显高于持续应答者（P=0.02，0.004，分别）。总之，这项研究表明 KIR 基因及其配体与慢性丙型肝炎病毒基因型 3a 感染抗病毒治疗的结果有关。
