Tran Dinh Nguyen, Vu Minh Phuc, Ha Manh Tuan, Giang Tran Phuong Linh, Komase Katsuhiro, Mizuguchi Masashi, Ushijima Hiroshi
Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Clin Lab. 2011;57(5-6):397-401.
Rubella virus (RV) infection during the first trimester of pregnancy often leads to severe birth defects known as congenital rubella syndrome (CRS).
A premature newborn male was clinically diagnosed as CRS with cataracts, congenital heart defects, microcephaly, hepatosplenomegaly, and thrombocytopenia. The infection was confirmed serologically and molecularly.
The RV was characterized and clustered with the 2B genotype.
The integrated description of clinical features, serological and molecular data provide a baseline for diagnosis and control of rubella and CRS in Vietnam. This is the first report of molecular investigation of wildtype RV strain in Vietnam, thus contributing to the documentation of RV's worldwide distribution.
孕期头三个月感染风疹病毒（RV）通常会导致严重的出生缺陷，即先天性风疹综合征（CRS）。
一名早产男婴经临床诊断为患有CRS，伴有白内障、先天性心脏缺陷、小头畸形、肝脾肿大和血小板减少症。通过血清学和分子学方法确认了感染情况。
对该风疹病毒进行了特征分析，并归类为2B基因型。
临床特征、血清学和分子数据的综合描述为越南风疹和CRS的诊断与控制提供了基线。这是越南野生型风疹病毒株分子研究的首例报告，有助于记录风疹病毒在全球的分布情况。
